SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		5 / 12 GLY A  98
VAL A  89
LEU A  11
MET A 168
LEU A 170
 None
 1.43A 1nhzA-2a22A:
undetectable		 1nhzA-2a22A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		5 / 12 PHE A 165
GLY A 148
LEU A 145
LEU A  32
VAL A 127
 None
 1.04A 3av6A-2a22A:
undetectable		 3av6A-2a22A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 5 LEU A  15
THR A 151
THR A  43
HIS A 101
 None
 1.36A 3ce6B-2a22A:
undetectable		 3ce6B-2a22A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 7 ASP A  14
GLY A  13
HIS A 101
CYH A  42
 None
 0.73A 4c5nA-2a22A:
undetectable		 4c5nA-2a22A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 7 GLY A  93
TYR A  39
ASN A  38
GLU A  94
 None
 0.98A 4fgkB-2a22A:
undetectable		 4fgkB-2a22A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 7 THR A  43
LEU A 167
GLN A 171
LEU A 170
 None
 0.85A 4ib4A-2a22A:
undetectable		 4ib4A-2a22A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 8 LEU A  10
ILE A  64
THR A 151
LEU A  24
 None
 0.89A 5eseA-2a22A:
undetectable		 5eseA-2a22A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 6 MET A 168
ASN A  61
VAL A  40
LEU A  11
 None
 1.07A 5xdhA-2a22A:
undetectable
5xdhC-2a22A:
undetectable		 5xdhA-2a22A:
18.18
5xdhC-2a22A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 4 VAL A  65
GLY A  44
ASP A  70
ASP A  68
 None
 1.43A 6cjkC-2a22A:
undetectable		 6cjkC-2a22A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2a22 VACUOLAR PROTEIN
SORTING 29
(Cryptosporidium
parvum) 		4 / 6 ALA A 161
GLY A 129
THR A  43
ILE A  12
 None
 0.89A 6f8cA-2a22A:
undetectable		 6f8cA-2a22A:
15.96