SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABK_W_CHDW1059_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2a24	ENDOTHELIAL PAS DOMAIN PROTEIN 1 (Homo sapiens)	4 / 5	ILE A 101 TYR A 45 MET A 53 THR A 54	None	1.13A	3abkN-2a24A: undetectable 3abkW-2a24A: undetectable	3abkN-2a24A: 10.46 3abkW-2a24A: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QOW_A_SAMA417_1 (HISTONE-LYSINE N-METHYLTRANSFERASE)	2a24	ENDOTHELIAL PAS DOMAIN PROTEIN 1 (Homo sapiens)	3 / 3	THR A 19 ASP A 15 GLU A 43	None	0.67A	3qowA-2a24A: undetectable	3qowA-2a24A: 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXD_C_RBVC502_2 (ADENOSYLHOMOCYSTEINA SE)	2a24	ENDOTHELIAL PAS DOMAIN PROTEIN 1 (Homo sapiens)	3 / 3	THR A 85 HIS A 32 LEU A 36	None	0.88A	5axdC-2a24A: undetectable	5axdC-2a24A: 14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FA8_A_SAMA301_1 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE)	2a24	ENDOTHELIAL PAS DOMAIN PROTEIN 1 (Homo sapiens)	3 / 3	THR A 19 ASP A 15 GLU A 43	None	0.66A	5fa8A-2a24A: undetectable	5fa8A-2a24A: 17.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ABK_W_CHDW1059_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2a24","ENDOTHELIAL PAS DOMAIN PROTEIN 1","Homo sapiens",4,"ILE A 101;TYR A  45;MET A  53;THR A  54","None","1.13A","3abkN-2a24A:undetectable;3abkW-2a24A:undetectable","3abkN-2a24A:10.46;3abkW-2a24A:19.05"],["3QOW_A_SAMA417_1","HISTONE-LYSINE N-METHYLTRANSFERASE","2a24","ENDOTHELIAL PAS DOMAIN PROTEIN 1","Homo sapiens",3,"THR A  19;ASP A  15;GLU A  43","None","0.67A","3qowA-2a24A:undetectable","3qowA-2a24A:13.96"],["5AXD_C_RBVC502_2","ADENOSYLHOMOCYSTEINASE","2a24","ENDOTHELIAL PAS DOMAIN PROTEIN 1","Homo sapiens",3,"THR A  85;HIS A  32;LEU A  36","None","0.88A","5axdC-2a24A:undetectable","5axdC-2a24A:14.67"],["5FA8_A_SAMA301_1","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE, PUTATIVE","2a24","ENDOTHELIAL PAS DOMAIN PROTEIN 1","Homo sapiens",3,"THR A  19;ASP A  15;GLU A  43","None","0.66A","5fa8A-2a24A:undetectable","5fa8A-2a24A:17.68"]]