SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
None
 0.58A 1fmoE-2a2aA:
28.6		 1fmoE-2a2aA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
 0.45A 1uwhA-2a2aA:
24.1		 1uwhA-2a2aA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
None
 0.52A 1uwhB-2a2aA:
23.9		 1uwhB-2a2aA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
None
 0.55A 1uwjA-2a2aA:
6.6		 1uwjA-2a2aA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 None
 0.73A 1xkkA-2a2aA:
22.9		 1xkkA-2a2aA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU A  19
ALA A  40
ILE A  77
LEU A  93
ILE A 160
 None
GOL  A3001 (-3.5A)
GOL  A3001 (-4.8A)
GOL  A3001 ( 4.5A)
GOL  A3001 ( 3.9A)
 0.84A 1yi4A-2a2aA:
27.4		 1yi4A-2a2aA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
ASP A 139
LYS A 141
ASN A 144
MET A 146
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.4A)
None
 0.77A 2fumA-2a2aA:
27.2		 2fumA-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
None
None
None
 0.58A 2fumA-2a2aA:
27.2		 2fumA-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
ASN A 144
MET A 146
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 (-4.4A)
None
 0.77A 2fumB-2a2aA:
27.0		 2fumB-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
None
None
 0.62A 2fumB-2a2aA:
27.0		 2fumB-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
GOL  A3001 (-4.4A)
 0.87A 2fumC-2a2aA:
25.2		 2fumC-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
GLY A  22
VAL A  27
ALA A  40
LYS A 141
ASN A 144
 None
None
None
None
GOL  A3001 (-3.5A)
None
None
 0.59A 2fumD-2a2aA:
25.4		 2fumD-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
GLY A  22
VAL A  27
LYS A 141
ASN A 144
MET A 146
 None
None
None
None
None
None
GOL  A3001 (-4.4A)
 0.97A 2fumD-2a2aA:
25.4		 2fumD-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
ASP A 161
 None
 0.90A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 None
 0.68A 2ivuA-2a2aA:
26.3		 2ivuA-2a2aA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 5 ALA A 214
GLN A 299
ILE A 209
ARG A 303
 None
 1.10A 2z0aA-2a2aA:
1.2		 2z0aA-2a2aA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 120
ILE A 252
ALA A 248
THR A 244
VAL A 291
 None
None
None
NA  A3178 (-3.0A)
NA  A3178 ( 4.4A)
 1.15A 3a51E-2a2aA:
undetectable		 3a51E-2a2aA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 LEU A 159
ASP A 199
TRP A 274
HIS A 272
 None
 1.17A 3asoC-2a2aA:
1.8
3asoN-2a2aA:
1.8
3asoP-2a2aA:
1.9		 3asoC-2a2aA:
22.82
3asoN-2a2aA:
19.52
3asoP-2a2aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 (-4.8A)
None
 0.54A 3gp0A-2a2aA:
22.6		 3gp0A-2a2aA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.8A)
 0.52A 3hecA-2a2aA:
22.3		 3hecA-2a2aA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 GOL  A3001 (-3.5A)
None
None
None
None
 0.51A 3hecA-2a2aA:
22.3		 3hecA-2a2aA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 None
GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.8A)
 0.94A 3hegA-2a2aA:
22.1		 3hegA-2a2aA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 ALA A 269
LEU A 255
VAL A 127
ILE A 206
ILE A 123
 None
 1.13A 3jw3B-2a2aA:
undetectable		 3jw3B-2a2aA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 GOL  A3001 (-3.5A)
None
None
None
None
 0.40A 3lfaA-2a2aA:
21.8		 3lfaA-2a2aA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 None
 0.53A 3ohtA-2a2aA:
4.1		 3ohtA-2a2aA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 None
 0.53A 3ohtB-2a2aA:
3.2		 3ohtB-2a2aA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 (-4.8A)
None
None
 0.56A 3rgfA-2a2aA:
7.4		 3rgfA-2a2aA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.8A)
GOL  A3001 ( 3.9A)
None
 0.60A 3warA-2a2aA:
27.5		 3warA-2a2aA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 0.66A 3warA-2a2aA:
27.5		 3warA-2a2aA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.58A 3wzeA-2a2aA:
22.4		 3wzeA-2a2aA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 ASP A 199
GLY A 204
THR A 207
ILE A 206
 None
 0.75A 4acaC-2a2aA:
undetectable		 4acaC-2a2aA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.53A 4agcA-2a2aA:
21.9		 4agcA-2a2aA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.55A 4asdA-2a2aA:
22.3		 4asdA-2a2aA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  19
VAL A  27
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 None
 0.76A 4asdA-2a2aA:
22.3		 4asdA-2a2aA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
 None
None
None
GOL  A3001 ( 3.9A)
None
 0.98A 4c49A-2a2aA:
undetectable		 4c49A-2a2aA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A  27
ALA A  40
ASP A 139
LYS A 141
ASN A 144
ILE A 160
ASP A 161
 None
GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 ( 3.9A)
None
 0.61A 4i41A-2a2aA:
27.3		 4i41A-2a2aA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 11 VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLU A 143
ILE A 160
ASP A 161
 None
GOL  A3001 (-3.5A)
None
GOL  A3001 ( 4.5A)
None
GOL  A3001 ( 3.9A)
None
 0.65A 4iaaA-2a2aA:
27.0		 4iaaA-2a2aA:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 GLY A  22
VAL A  27
ALA A  40
LYS A  42
 None
None
GOL  A3001 (-3.5A)
None
 0.26A 4l9iB-2a2aA:
26.2		 4l9iB-2a2aA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 ( 4.5A)
None
None
 0.63A 4mkcA-2a2aA:
25.3		 4mkcA-2a2aA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 11 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
None
None
None
 0.88A 4o0sA-2a2aA:
29.8		 4o0sA-2a2aA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
 None
None
None
GOL  A3001 (-3.5A)
 0.22A 4o0wA-2a2aA:
28.5		 4o0wA-2a2aA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 GOL  A3001 (-3.5A)
None
GOL  A3001 (-4.8A)
None
GOL  A3001 (-3.8A)
 0.54A 4rz7A-2a2aA:
10.6		 4rz7A-2a2aA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 None
GOL  A3001 (-3.5A)
None
None
None
None
 0.37A 4wkqA-2a2aA:
25.5		 4wkqA-2a2aA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
 None
GOL  A3001 (-3.5A)
None
None
None
 0.62A 4xv2A-2a2aA:
24.1		 4xv2A-2a2aA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 GOL  A3001 (-3.5A)
None
None
None
None
 0.71A 4xv2B-2a2aA:
24.2		 4xv2B-2a2aA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 LEU A  19
GLY A  20
VAL A  27
LEU A  95
GLY A  99
 None
 0.99A 4zauA-2a2aA:
25.0		 4zauA-2a2aA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 None
GOL  A3001 (-3.5A)
None
None
None
 0.69A 5cswA-2a2aA:
24.1		 5cswA-2a2aA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 None
GOL  A3001 (-3.5A)
None
None
None
 0.75A 5cswB-2a2aA:
24.2		 5cswB-2a2aA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ASN A 280
ALA A 283
ARG A 287
 None
 0.76A 5cvtB-2a2aA:
undetectable		 5cvtB-2a2aA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 GOL  A3001 (-3.5A)
None
None
None
None
None
 0.64A 5hi2A-2a2aA:
24.3		 5hi2A-2a2aA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 GLY A  20
LEU A  79
ASP A 161
PHE A 162
 None
 0.89A 5hieB-2a2aA:
23.2		 5hieB-2a2aA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 None
 0.33A 5izjA-2a2aA:
28.2		 5izjA-2a2aA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 None
 0.42A 5j5xA-2a2aA:
28.3		 5j5xA-2a2aA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 ( 4.5A)
None
 0.38A 5lvnA-2a2aA:
29.7		 5lvnA-2a2aA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-4.8A)
None
 0.45A 5lw1E-2a2aA:
22.8		 5lw1E-2a2aA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
 None
None
None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 ( 4.5A)
 0.65A 5mafA-2a2aA:
29.0		 5mafA-2a2aA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 ( 4.5A)
None
GOL  A3001 ( 3.9A)
 0.76A 5mafA-2a2aA:
29.0		 5mafA-2a2aA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.54A 5vcyA-2a2aA:
25.4		 5vcyA-2a2aA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 LEU A 159
ASP A 199
TRP A 274
HIS A 272
 None
 1.10A 5w97C-2a2aA:
2.4
5w97a-2a2aA:
undetectable
5w97c-2a2aA:
2.4		 5w97C-2a2aA:
22.82
5w97a-2a2aA:
19.52
5w97c-2a2aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.81A 5y7zB-2a2aA:
26.8		 5y7zB-2a2aA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
 0.63A 5y80A-2a2aA:
25.9		 5y80A-2a2aA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 ( 3.9A)
None
 0.56A 5y9mA-2a2aA:
17.7		 5y9mA-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.05A 5y9mA-2a2aA:
17.7		 5y9mA-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 ( 3.9A)
None
 0.58A 5y9mX-2a2aA:
21.7		 5y9mX-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.18A 5yf9B-2a2aA:
26.8		 5yf9B-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 (-4.8A)
GOL  A3001 ( 3.9A)
None
 0.72A 5yf9X-2a2aA:
27.4		 5yf9X-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.17A 5yf9X-2a2aA:
27.4		 5yf9X-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.8A)
GOL  A3001 ( 3.9A)
None
 0.46A 5ywmX-2a2aA:
27.2		 5ywmX-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ALA A  40
VAL A   9
TYR A  13
 GOL  A3001 (-3.5A)
None
None
 0.65A 5zmqH-2a2aA:
1.1		 5zmqH-2a2aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.58A 5zv2B-2a2aA:
22.4		 5zv2B-2a2aA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 264
GLY A 204
PHE A 236
 None
 0.65A 6exiC-2a2aA:
undetectable		 6exiC-2a2aA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 HIS A 243
ASN A 292
LEU A 293
 None
 0.71A 6f7lB-2a2aA:
undetectable		 6f7lB-2a2aA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 LEU A 159
ASP A 199
TRP A 274
HIS A 272
 None
 1.12A 6nknC-2a2aA:
undetectable
6nknN-2a2aA:
undetectable
6nknP-2a2aA:
undetectable		 6nknC-2a2aA:
22.82
6nknN-2a2aA:
19.52
6nknP-2a2aA:
22.82