SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 363
ILE A  51
GLY A  48
LEU A  59
 None
 1.14A 1g50B-2a2dA:
undetectable		 1g50B-2a2dA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 11 LEU A 343
LEU A 363
ILE A  51
GLY A  48
LEU A  59
 None
 1.14A 1g50C-2a2dA:
undetectable		 1g50C-2a2dA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 8 THR A 128
GLY A 117
LEU A 115
GLY A 155
 None
 0.76A 1jhvA-2a2dA:
undetectable		 1jhvA-2a2dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 4 LEU A 382
VAL A 386
CYH A 389
ALA A 394
 None
 1.28A 1mz9E-2a2dA:
undetectable		 1mz9E-2a2dA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		3 / 3 TRP A 262
LEU A 260
LYS A 274
 None
 1.19A 1yajK-2a2dA:
undetectable		 1yajK-2a2dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 8 LEU A 249
ILE A 315
ILE A 300
ILE A 306
 None
 0.80A 2bu8A-2a2dA:
undetectable		 2bu8A-2a2dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 7 TYR A 110
SER A 147
SER A 141
ASN A 233
 ANP  A 461 (-4.1A)
MN  A 460 ( 2.3A)
ANP  A 461 (-3.9A)
ANP  A 461 (-3.3A)
 1.07A 2i91B-2a2dA:
undetectable		 2i91B-2a2dA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 5 SER A 367
GLY A 401
GLU A 338
CYH A 377
 None
ANP  A 461 ( 3.8A)
None
None
 0.99A 3aiaA-2a2dA:
undetectable
3aiaB-2a2dA:
undetectable		 3aiaA-2a2dA:
17.94
3aiaB-2a2dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 11 VAL A 134
GLY A 136
ILE A 138
SER A 146
SER A 148
 None
ANP  A 461 (-3.6A)
None
ANP  A 461 (-2.7A)
A2G  A 459 (-3.3A)
 1.30A 3bjwE-2a2dA:
undetectable		 3bjwE-2a2dA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 6 VAL A 424
LEU A 144
ILE A  46
LEU A 443
 None
 0.82A 3kk6A-2a2dA:
0.2		 3kk6A-2a2dA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 6 VAL A 424
LEU A 144
ILE A  46
ALA A 226
LEU A 443
 None
 0.83A 3kk6B-2a2dA:
0.0		 3kk6B-2a2dA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 12 ALA A 452
GLY A 449
VAL A  38
PRO A   6
LEU A 171
 None
 1.10A 3m6vA-2a2dA:
undetectable		 3m6vA-2a2dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 7 ALA A 226
SER A 410
VAL A 412
VAL A 224
 None
 0.88A 3o14A-2a2dA:
undetectable		 3o14A-2a2dA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 10 ALA A 149
LEU A  68
ILE A  69
ALA A  70
THR A 160
 None
 0.98A 3r9cA-2a2dA:
undetectable		 3r9cA-2a2dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 12 GLU A  49
ASN A  45
LEU A 144
ILE A 138
LEU A 150
 A2G  A 459 (-3.5A)
None
None
None
ANP  A 461 (-4.6A)
 1.22A 4k36B-2a2dA:
undetectable		 4k36B-2a2dA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 11 GLU A  49
ASN A  45
LEU A 144
ILE A 138
LEU A 150
 A2G  A 459 (-3.5A)
None
None
None
ANP  A 461 (-4.6A)
 1.17A 4k37B-2a2dA:
undetectable		 4k37B-2a2dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 6 ASP A 135
ALA A  70
TYR A  37
ASP A  66
 None
 0.82A 4mdaA-2a2dA:
undetectable		 4mdaA-2a2dA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 6 ASP A 135
ALA A  70
TYR A  37
ASP A  66
 None
 0.79A 4mdbA-2a2dA:
undetectable		 4mdbA-2a2dA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 6 LEU A 275
GLU A 269
VAL A 335
ALA A 332
 None
 1.05A 4nkvC-2a2dA:
undetectable		 4nkvC-2a2dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 10 VAL A 134
GLY A 114
ILE A 118
VAL A  71
ILE A  69
 None
 1.06A 4q1wB-2a2dA:
undetectable		 4q1wB-2a2dA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		3 / 3 SER A 219
ALA A 221
VAL A 222
 None
 0.65A 4x20C-2a2dA:
undetectable		 4x20C-2a2dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 5 SER A 146
ARG A 180
GLY A 183
GLU A 185
 ANP  A 461 (-2.7A)
None
None
None
 1.19A 5btiA-2a2dA:
0.9
5btiB-2a2dA:
undetectable		 5btiA-2a2dA:
22.48
5btiB-2a2dA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 12 GLU A 185
GLY A 186
GLU A 338
CYH A 377
CYH A 371
 None
A2G  A 459 (-3.3A)
None
None
None
 1.50A 5fhzD-2a2dA:
undetectable		 5fhzD-2a2dA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		4 / 6 VAL A 412
LEU A 417
CYH A 389
LEU A 443
 None
 1.11A 5hrqB-2a2dA:
undetectable
5hrqI-2a2dA:
undetectable
5hrqJ-2a2dA:
undetectable		 5hrqB-2a2dA:
5.29
5hrqI-2a2dA:
4.75
5hrqJ-2a2dA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens) 		5 / 9 ILE A  47
LEU A 360
GLY A 361
ASN A 365
ALA A 221
 None
 1.42A 5x66C-2a2dA:
undetectable		 5x66C-2a2dA:
19.29