SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 9 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.43A 2idwB-2a2fX:
undetectable		 2idwB-2a2fX:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		4 / 8 PHE X 288
THR X 250
THR X 231
ILE X 225
 None
 0.95A 2qbmA-2a2fX:
undetectable		 2qbmA-2a2fX:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.47A 2rkfB-2a2fX:
undetectable		 2rkfB-2a2fX:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.50A 2rkgA-2a2fX:
undetectable		 2rkgA-2a2fX:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		4 / 5 GLN X 284
ALA X 217
GLN X 277
ILE X 221
 None
 1.40A 2z0aA-2a2fX:
2.5		 2z0aA-2a2fX:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		4 / 6 GLU X 167
ALA X 107
ASN X 103
ALA X 106
 None
 1.20A 2zgwB-2a2fX:
undetectable		 2zgwB-2a2fX:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.38A 3bvbB-2a2fX:
undetectable		 3bvbB-2a2fX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 11 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.37A 3ektC-2a2fX:
undetectable		 3ektC-2a2fX:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 11 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 242
 None
 1.01A 3el1A-2a2fX:
undetectable		 3el1A-2a2fX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		3 / 3 PHE X 288
TYR X 227
LEU X 280
 None
 0.68A 3keeB-2a2fX:
undetectable		 3keeB-2a2fX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.38A 3lzuB-2a2fX:
undetectable		 3lzuB-2a2fX:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 242
 None
 1.00A 3oxxA-2a2fX:
undetectable		 3oxxA-2a2fX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 11 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 242
 None
 0.99A 3oxxB-2a2fX:
undetectable		 3oxxB-2a2fX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 11 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 242
 None
 0.99A 3oxxD-2a2fX:
undetectable		 3oxxD-2a2fX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.36A 3s54B-2a2fX:
undetectable		 3s54B-2a2fX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		3 / 3 PHE X 288
TYR X 227
LEU X 280
 None
 0.79A 3sueB-2a2fX:
undetectable		 3sueB-2a2fX:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.45A 3tl9A-2a2fX:
undetectable		 3tl9A-2a2fX:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 10 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.43A 4dqfB-2a2fX:
undetectable		 4dqfB-2a2fX:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 10 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.38A 4ll3A-2a2fX:
undetectable		 4ll3A-2a2fX:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		3 / 3 HIS X 179
VAL X  80
LEU X 149
 None
 0.74A 4m2vA-2a2fX:
undetectable		 4m2vA-2a2fX:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 12 CYH X 124
PHE X 121
LEU X 149
VAL X  27
SER X  74
 None
 1.31A 4po0A-2a2fX:
2.7		 4po0A-2a2fX:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		6 / 12 LEU X 239
ALA X 185
ASP X 184
GLY X 190
ILE X 193
ILE X 242
 None
 1.40A 5e5kA-2a2fX:
undetectable		 5e5kA-2a2fX:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 10 VAL X  27
TRP X  24
LEU X 125
PHE X 121
ILE X  51
 None
 1.08A 5hw8C-2a2fX:
undetectable
5hw8H-2a2fX:
undetectable		 5hw8C-2a2fX:
15.72
5hw8H-2a2fX:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		3 / 3 VAL X  77
LYS X  85
MET X  88
 None
 1.02A 5nknA-2a2fX:
undetectable		 5nknA-2a2fX:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 11 VAL X 294
ALA X 243
TYR X 305
GLU X 301
ALA X 246
 None
 1.42A 6dk1C-2a2fX:
undetectable		 6dk1C-2a2fX:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		5 / 11 VAL X 294
TYR X 305
LEU X 302
GLU X 301
ALA X 246
 None
 1.23A 6dk1C-2a2fX:
undetectable		 6dk1C-2a2fX:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2a2f EXOCYST COMPLEX
COMPONENT SEC15
(Drosophila
melanogaster) 		3 / 3 LEU X 302
LEU X 297
ARG X 248
 None
 0.66A 6fgdA-2a2fX:
undetectable		 6fgdA-2a2fX:
20.83