SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E06_A_IPBA600_0 (ODORANT-BINDING PROTEIN)	2a2g	PROTEIN (ALPHA-2U-GLOBULIN) (Rattus norvegicus)	4 / 6	VAL A 40 MET A 42 VAL A 82 ASN A 88	LEO A 201 ( 4.8A) None None None	0.55A	1e06A-2a2gA: 22.9	1e06A-2a2gA: 25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EA1_A_TPFA470_1 (CYTOCHROME P450 51-LIKE RV0764C)	2a2g	PROTEIN (ALPHA-2U-GLOBULIN) (Rattus norvegicus)	4 / 8	TYR A 80 PHE A 90 THR A 95 LEU A 15	None LEO A 201 ( 4.2A) None None	1.09A	1ea1A-2a2gA: undetectable	1ea1A-2a2gA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NT2_A_SAMA301_0 (FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN)	2a2g	PROTEIN (ALPHA-2U-GLOBULIN) (Rattus norvegicus)	5 / 12	TYR A 68 GLY A 53 TYR A 80 ASP A 46 ILE A 45	None	1.18A	1nt2A-2a2gA: undetectable	1nt2A-2a2gA: 24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_0 (GLYCINE N-METHYLTRANSFERASE)	2a2g	PROTEIN (ALPHA-2U-GLOBULIN) (Rattus norvegicus)	4 / 6	LEU A 93 HIS A 104 THR A 6 ARG A 7	None	1.25A	3thrB-2a2gA: undetectable	3thrB-2a2gA: 23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HUO_D_08HD501_0 (GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOB UTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2)	2a2g	PROTEIN (ALPHA-2U-GLOBULIN) (Rattus norvegicus)	4 / 8	PHE A 90 PHE A 54 VAL A 101 TYR A 120	LEO A 201 ( 4.2A) LEO A 201 (-4.0A) None LEO A 201 (-4.6A)	0.90A	6huoC-2a2gA: undetectable 6huoD-2a2gA: undetectable	6huoC-2a2gA: 20.93 6huoD-2a2gA: 19.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E06_A_IPBA600_0","ODORANT-BINDING PROTEIN","2a2g","PROTEIN (ALPHA-2U-GLOBULIN)","Rattus norvegicus",4,"VAL A  40;MET A  42;VAL A  82;ASN A  88","LEO A 201 ( 4.8A);None;None;None","0.55A","1e06A-2a2gA:22.9","1e06A-2a2gA:25.97"],["1EA1_A_TPFA470_1","CYTOCHROME P450 51-LIKE RV0764C","2a2g","PROTEIN (ALPHA-2U-GLOBULIN)","Rattus norvegicus",4,"TYR A  80;PHE A  90;THR A  95;LEU A  15","None;LEO A 201 ( 4.2A);None;None","1.09A","1ea1A-2a2gA:undetectable","1ea1A-2a2gA:18.85"],["1NT2_A_SAMA301_0","FIBRILLARIN-LIKE PRE-RRNA PROCESSING PROTEIN","2a2g","PROTEIN (ALPHA-2U-GLOBULIN)","Rattus norvegicus",5,"TYR A  68;GLY A  53;TYR A  80;ASP A  46;ILE A  45","None","1.18A","1nt2A-2a2gA:undetectable","1nt2A-2a2gA:24.55"],["3THR_A_C2FA1100_0","GLYCINE N-METHYLTRANSFERASE","2a2g","PROTEIN (ALPHA-2U-GLOBULIN)","Rattus norvegicus",4,"LEU A  93;HIS A 104;THR A   6;ARG A   7","None","1.25A","3thrB-2a2gA:undetectable","3thrB-2a2gA:23.59"],["6HUO_D_08HD501_0","GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2","2a2g","PROTEIN (ALPHA-2U-GLOBULIN)","Rattus norvegicus",4,"PHE A  90;PHE A  54;VAL A 101;TYR A 120","LEO A 201 ( 4.2A);LEO A 201 (-4.0A);None;LEO A 201 (-4.6A)","0.90A","6huoC-2a2gA:undetectable;6huoD-2a2gA:undetectable","6huoC-2a2gA:20.93;6huoD-2a2gA:19.44"]]