SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 151
VAL A 184
PRO A 185
 None
 0.71A 1rg1A-2a2jA:
undetectable		 1rg1A-2a2jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 151
VAL A 184
PRO A 185
 None
 0.71A 1rh0A-2a2jA:
undetectable		 1rh0A-2a2jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  65
VAL A 127
VAL A  88
TYR A 191
 None
 1.04A 4puoC-2a2jA:
undetectable		 4puoC-2a2jA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  65
VAL A 127
VAL A  88
TYR A 191
 None
 1.03A 4pwdA-2a2jA:
undetectable		 4pwdA-2a2jA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  37
LEU A 219
ALA A 121
LEU A  44
LEU A  83
 None
 1.10A 6ew0B-2a2jA:
undetectable		 6ew0B-2a2jA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  37
LEU A 219
ALA A 121
LEU A  44
LEU A  83
 None
 1.10A 6ew0D-2a2jA:
undetectable		 6ew0D-2a2jA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  37
LEU A 219
ALA A 121
LEU A  44
LEU A  83
 None
 1.10A 6ew0H-2a2jA:
undetectable		 6ew0H-2a2jA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  37
LEU A 219
ALA A 121
LEU A  44
LEU A  83
 None
 1.10A 6ew0I-2a2jA:
undetectable		 6ew0I-2a2jA:
13.82