SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2a2l UNKNOWN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 107
SER A 143
GLN A 136
HIS A  79
VAL A 128
 None
 1.36A 1qu3A-2a2lA:
undetectable		 1qu3A-2a2lA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2a2l UNKNOWN
(Klebsiella
pneumoniae) 		3 / 3 PHE A 105
LYS A  67
SER A  70
 None
 0.92A 3tyeB-2a2lA:
undetectable		 3tyeB-2a2lA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2a2l UNKNOWN
(Klebsiella
pneumoniae) 		4 / 7 ILE A  32
GLN A 130
GLY A 126
VAL A  36
 None
 0.93A 4a3uB-2a2lA:
undetectable		 4a3uB-2a2lA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a2l UNKNOWN
(Klebsiella
pneumoniae) 		4 / 8 SER A  64
VAL A 123
VAL A 111
GLY A 119
 None
 0.98A 4mk4A-2a2lA:
undetectable		 4mk4A-2a2lA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2a2l UNKNOWN
(Klebsiella
pneumoniae) 		4 / 8 GLN A 100
GLY A  93
ILE A 104
GLN A  76
 None
 0.83A 5vlmH-2a2lA:
0.0		 5vlmH-2a2lA:
24.87