SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2a2n PEPTIDYLPROLYL
ISOMERASE DOMAIN AND
WD REPEAT CONTAINING
1
(Homo
sapiens) 		4 / 6 SER A 523
PHE A 592
ILE A 594
PHE A 533
 None
 1.29A 2qeiA-2a2nA:
undetectable		 2qeiA-2a2nA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2a2n PEPTIDYLPROLYL
ISOMERASE DOMAIN AND
WD REPEAT CONTAINING
1
(Homo
sapiens) 		4 / 5 LEU A 507
GLY A 610
PHE A 609
PHE A 519
 None
 1.09A 3smtA-2a2nA:
undetectable		 3smtA-2a2nA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2a2n PEPTIDYLPROLYL
ISOMERASE DOMAIN AND
WD REPEAT CONTAINING
1
(Homo
sapiens) 		4 / 7 ILE A 542
PHE A 533
VAL A 619
ILE A 503
 None
 0.85A 4zzbC-2a2nA:
undetectable
4zzbD-2a2nA:
undetectable		 4zzbC-2a2nA:
19.62
4zzbD-2a2nA:
19.62