SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 199
VAL A  32
TRP A  40
 None
 0.75A 1jnoA-2a2oA:
undetectable		 1jnoA-2a2oA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 199
VAL A  32
TRP A  40
 None
 0.75A 1jnoB-2a2oA:
undetectable		 1jnoB-2a2oA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 199
VAL A  32
TRP A  40
 None
 0.79A 1ng8A-2a2oA:
undetectable		 1ng8A-2a2oA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 199
VAL A  32
TRP A  40
 None
 0.79A 1ng8B-2a2oA:
undetectable		 1ng8B-2a2oA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A  25
LEU A  28
PHE A 105
LEU A 102
TYR A 209
 None
 1.15A 2f7aA-2a2oA:
undetectable		 2f7aA-2a2oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  57
THR A 179
PRO A 180
 None
 0.60A 2pynB-2a2oA:
undetectable		 2pynB-2a2oA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  57
THR A 179
PRO A 180
 None
 0.64A 2q64B-2a2oA:
undetectable		 2q64B-2a2oA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  57
THR A 179
PRO A 180
 None
 0.64A 2qakB-2a2oA:
undetectable		 2qakB-2a2oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		4 / 4 ALA A 146
TYR A 147
ALA A 142
TYR A 144
 None
 1.15A 2wlkA-2a2oA:
2.0
2wlkB-2a2oA:
2.1		 2wlkA-2a2oA:
21.10
2wlkB-2a2oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A 237
PRO A  69
GLY A  65
TYR A 185
ALA A  71
 None
 1.39A 3pp7B-2a2oA:
undetectable		 3pp7B-2a2oA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A  57
THR A 179
PRO A 180
 None
 0.66A 3tkgD-2a2oA:
undetectable		 3tkgD-2a2oA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A 226
MET A 157
TYR A 166
 None
 0.85A 4p6xI-2a2oA:
undetectable		 4p6xI-2a2oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		4 / 8 LYS A 217
ALA A 218
LEU A  42
LEU A  38
 None
 0.86A 4po0A-2a2oA:
undetectable		 4po0A-2a2oA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  61
ALA A  63
PHE A 233
ILE A 189
ASP A  79
 None
None
EDO  A 249 ( 4.3A)
None
EDO  A 248 ( 4.1A)
 1.28A 4xe5A-2a2oA:
undetectable		 4xe5A-2a2oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2a2o HYPOTHETICAL PROTEIN
BT3146
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A  43
TRP A 170
PHE A 174
THR A 234
 None
 1.38A 5hqaA-2a2oA:
undetectable		 5hqaA-2a2oA:
16.92