SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 147
LEU A 192
LEU A 208
ALA A 188
 None
 0.77A 1e7cA-2a35A:
undetectable		 1e7cA-2a35A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  63
LEU A  62
HIS A  45
 None
 0.79A 1qknA-2a35A:
undetectable		 1qknA-2a35A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  70
LEU A 110
GLU A  28
ARG A  24
 None
 1.00A 2jn3A-2a35A:
undetectable		 2jn3A-2a35A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.02A 3n8zB-2a35A:
undetectable		 3n8zB-2a35A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 132
ARG A  87
LEU A  95
PRO A  94
 None
 1.30A 3onnA-2a35A:
3.1		 3onnA-2a35A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 133
GLY A 130
SER A 113
 None
 0.69A 4b53B-2a35A:
undetectable		 4b53B-2a35A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 102
ILE A  66
LEU A  59
LEU A  62
GLY A  64
 None
 1.20A 4l9qB-2a35A:
undetectable		 4l9qB-2a35A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 178
VAL A 112
LEU A 161
 None
 0.74A 4m2vA-2a35A:
undetectable		 4m2vA-2a35A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.09A 4otyA-2a35A:
undetectable		 4otyA-2a35A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.08A 4otyB-2a35A:
undetectable		 4otyB-2a35A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  10
LEU A 208
LEU A 161
LEU A 165
ILE A 164
 None
 1.01A 4zowA-2a35A:
undetectable		 4zowA-2a35A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.17A 5iktB-2a35A:
undetectable		 5iktB-2a35A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2a35 HYPOTHETICAL PROTEIN
PA4017
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 185
ASP A 184
GLY A 179
LEU A 189
LEU A  21
 None
 0.86A 5twjD-2a35A:
undetectable		 5twjD-2a35A:
23.35