SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		9 / 12 ALA A 145
TYR A 147
TYR A 171
ASP A 173
GLN A 175
GLU A 197
ASP A 199
GLU A 202
ASP A 349
 None
 0.53A 1dy4A-2a39A:
50.6		 1dy4A-2a39A:
40.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		5 / 12 LEU A 112
TYR A 119
GLY A 155
TYR A 110
GLY A 170
 None
 1.13A 1httB-2a39A:
undetectable		 1httB-2a39A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		4 / 6 MET A  75
SER A  35
PRO A 162
GLY A 163
 PCA  A   1 ( 4.0A)
None
None
None
 1.42A 2y7pA-2a39A:
0.0		 2y7pA-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		3 / 3 SER A  35
GLY A 170
GLY A 184
 None
None
PCA  A   1 ( 3.3A)
 0.45A 3bogA-2a39A:
undetectable
3bogC-2a39A:
undetectable		 3bogA-2a39A:
undetectable
3bogC-2a39A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		3 / 3 TYR A 167
TYR A  81
ILE A  78
 None
 0.81A 3eteA-2a39A:
undetectable
3eteB-2a39A:
undetectable		 3eteA-2a39A:
22.26
3eteB-2a39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		4 / 8 ASP A 134
THR A 385
TYR A 386
LEU A 138
 None
 1.20A 3x2qA-2a39A:
undetectable
3x2qC-2a39A:
undetectable
3x2qP-2a39A:
undetectable		 3x2qA-2a39A:
20.23
3x2qC-2a39A:
18.05
3x2qP-2a39A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		3 / 3 ASN A  29
LEU A 146
PHE A  16
 None
 0.63A 4dajB-2a39A:
undetectable		 4dajB-2a39A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		3 / 3 PHE A 177
TYR A 147
TYR A 171
 None
 1.11A 4ffwA-2a39A:
undetectable		 4ffwA-2a39A:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		9 / 9 ASN A 143
ALA A 145
TYR A 147
TYR A 171
ASP A 173
GLU A 197
ASP A 199
GLU A 202
TRP A 347
 None
 0.49A 4ipmA-2a39A:
51.2		 4ipmA-2a39A:
36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		4 / 4 TYR A 323
THR A 214
GLY A 331
LEU A 280
 None
 1.33A 4w5nA-2a39A:
0.0		 4w5nA-2a39A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		5 / 12 LEU A 112
TYR A 119
GLY A 155
TYR A 110
GLY A 170
 None
 1.20A 5e3iA-2a39A:
undetectable		 5e3iA-2a39A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		5 / 12 LEU A  13
ILE A  31
THR A 115
LEU A 389
LEU A 342
 None
 0.74A 5nfjA-2a39A:
undetectable		 5nfjA-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		5 / 12 LEU A  13
ILE A  31
THR A 115
LEU A 389
LEU A 342
 None
 0.78A 5nfjB-2a39A:
undetectable		 5nfjB-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		5 / 12 LEU A  13
ILE A  31
THR A 115
LEU A 389
LEU A 342
 None
 0.76A 5nfjC-2a39A:
undetectable		 5nfjC-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		3 / 3 VAL A  66
LYS A   2
MET A  75
 None
None
PCA  A   1 ( 4.0A)
 0.84A 5nknA-2a39A:
undetectable		 5nknA-2a39A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a39 ENDOGLUCANASE I
(Humicola
insolens) 		4 / 7 LEU A 138
ASP A 134
THR A 385
TYR A 386
 None
 1.21A 5wauC-2a39A:
undetectable
5waua-2a39A:
undetectable
5wauc-2a39A:
undetectable		 5wauC-2a39A:
18.05
5waua-2a39A:
20.23
5wauc-2a39A:
18.05