SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1fohA-2a3kA:
undetectable		 1fohA-2a3kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1fohB-2a3kA:
undetectable		 1fohB-2a3kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.44A 1fohC-2a3kA:
undetectable		 1fohC-2a3kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1pn0A-2a3kA:
undetectable		 1pn0A-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1pn0B-2a3kA:
undetectable		 1pn0B-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.45A 1pn0C-2a3kA:
undetectable		 1pn0C-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.44A 1pn0D-2a3kA:
undetectable		 1pn0D-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		3 / 3 LEU A 129
PRO A 130
LEU A 114
 None
 0.33A 2qd5B-2a3kA:
undetectable		 2qd5B-2a3kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		6 / 12 GLY A 294
VAL A 289
GLY A 332
MET A 333
LEU A 326
ILE A 155
 PO4  A 501 (-4.4A)
None
None
None
None
None
 1.36A 3ku1A-2a3kA:
undetectable		 3ku1A-2a3kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		6 / 12 GLY A 294
VAL A 289
GLY A 332
MET A 333
LEU A 326
ILE A 155
 PO4  A 501 (-4.4A)
None
None
None
None
None
 1.34A 3ku1C-2a3kA:
undetectable		 3ku1C-2a3kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 11 ILE A 166
ILE A 191
ILE A 150
VAL A 188
PRO A 286
 None
 0.97A 3tmzA-2a3kA:
undetectable		 3tmzA-2a3kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		3 / 3 LEU A 129
PRO A 130
LEU A 114
 None
 0.47A 3w1wB-2a3kA:
undetectable		 3w1wB-2a3kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
 None
 1.31A 4ci1B-2a3kA:
0.0		 4ci1B-2a3kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CI3_B_Y70B1429_1
(PROTEIN CEREBLON)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 10 PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
 None
 1.30A 4ci3B-2a3kA:
0.0		 4ci3B-2a3kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		4 / 6 GLU A 338
THR A 336
GLN A 259
THR A 304
 None
 1.38A 4pfjB-2a3kA:
undetectable		 4pfjB-2a3kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		5 / 12 PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
 None
 1.40A 5fqdE-2a3kA:
undetectable
5fqdF-2a3kA:
0.0		 5fqdE-2a3kA:
21.99
5fqdF-2a3kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens) 		4 / 6 GLU A 273
ALA A 272
LEU A 270
TYR A 231
 None
 0.79A 5phhA-2a3kA:
undetectable		 5phhA-2a3kA:
22.02