SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.77A 1a4lA-2a3lA:
20.7		 1a4lA-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.70A 1a4lB-2a3lA:
20.8		 1a4lB-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.72A 1a4lC-2a3lA:
20.8		 1a4lC-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.65A 1a4lD-2a3lA:
20.5		 1a4lD-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 11 TYR A 517
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.20A 1c3sA-2a3lA:
undetectable		 1c3sA-2a3lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 PHE A 563
TYR A 631
LEU A 547
VAL A 560
 None
 1.34A 1dz6A-2a3lA:
0.0		 1dz6A-2a3lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 PRO A 722
VAL A 723
ARG A 727
VAL A 758
TRP A 759
 None
 1.34A 1hrkB-2a3lA:
undetectable		 1hrkB-2a3lA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 729
LEU A 355
LEU A 697
GLN A 699
 None
 0.93A 1kt3A-2a3lA:
undetectable		 1kt3A-2a3lA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 539
ASN A 540
TRP A 787
 None
 0.96A 1r15C-2a3lA:
undetectable		 1r15C-2a3lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 539
ASN A 540
TRP A 787
 None
 0.89A 1r15D-2a3lA:
0.8		 1r15D-2a3lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 539
ASN A 540
TRP A 787
 None
 0.94A 1r15E-2a3lA:
undetectable		 1r15E-2a3lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 539
ASN A 540
TRP A 787
 None
 0.95A 1r15F-2a3lA:
undetectable		 1r15F-2a3lA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 PHE A 328
TYR A 261
LEU A 674
THR A 330
 None
 1.11A 1rmtB-2a3lA:
undetectable		 1rmtB-2a3lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 PHE A 328
TYR A 261
LEU A 674
THR A 330
 None
 1.04A 1rmtD-2a3lA:
undetectable		 1rmtD-2a3lA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 SER A 562
PHE A 563
ASN A 565
ASP A 568
 None
 1.30A 1rs6A-2a3lA:
undetectable		 1rs6A-2a3lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 1t69A-2a3lA:
undetectable		 1t69A-2a3lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 712
TYR A 467
HIS A 393
HIS A 659
HIS A 391
 None
CF5  A 841 (-2.7A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
 1.36A 1tmxB-2a3lA:
undetectable		 1tmxB-2a3lA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 TYR A 631
ALA A 637
ALA A 325
PRO A 617
GLY A 305
 None
 1.14A 2igtA-2a3lA:
undetectable		 2igtA-2a3lA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 TYR A 631
ALA A 637
ALA A 325
PRO A 617
GLY A 305
 None
 1.16A 2igtB-2a3lA:
undetectable		 2igtB-2a3lA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 VAL A 774
ASN A 772
ALA A 703
ARG A 513
 None
 0.93A 2ij7C-2a3lA:
undetectable		 2ij7C-2a3lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 HIS A 394
ALA A 510
VAL A 541
THR A 495
 None
 0.80A 2it4A-2a3lA:
undetectable		 2it4A-2a3lA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 HIS A 334
ILE A 339
LEU A 694
 None
 0.66A 2kceA-2a3lA:
undetectable		 2kceA-2a3lA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 ASP A 601
HIS A 659
HIS A 681
SER A 708
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.47A 2pgfA-2a3lA:
20.8		 2pgfA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
SER A 708
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.74A 2pgfA-2a3lA:
20.8		 2pgfA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 391
ASP A 601
HIS A 659
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
None
ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 2pgrA-2a3lA:
20.8		 2pgrA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.72A 2pgrA-2a3lA:
20.8		 2pgrA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 544
ASP A 598
ILE A 679
GLU A 511
 None
 1.03A 2qqdA-2a3lA:
undetectable
2qqdE-2a3lA:
undetectable		 2qqdA-2a3lA:
6.18
2qqdE-2a3lA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 769
ALA A 755
PHE A 725
ASN A 360
ARG A 815
 None
 1.14A 2w3mB-2a3lA:
undetectable		 2w3mB-2a3lA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 391
HIS A 659
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.17A 3c0zA-2a3lA:
undetectable		 3c0zA-2a3lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 6 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 3c0zC-2a3lA:
undetectable		 3c0zC-2a3lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 9 PHE A 724
VAL A 731
GLY A 701
VAL A 723
GLY A 728
 None
 1.33A 3kmoA-2a3lA:
undetectable		 3kmoA-2a3lA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 6 HIS A 681
HIS A 659
HIS A 391
ASP A 737
 CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 0.78A 3nvcA-2a3lA:
undetectable		 3nvcA-2a3lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 736
SER A 705
HIS A 391
ASP A 737
 CF5  A 841 ( 2.5A)
None
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 1.04A 3sg9B-2a3lA:
undetectable		 3sg9B-2a3lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 736
SER A 734
HIS A 391
ASP A 737
 CF5  A 841 ( 2.5A)
None
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 0.94A 3sg9B-2a3lA:
undetectable		 3sg9B-2a3lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 LYS A 592
VAL A 589
HIS A 588
 None
 1.11A 3tj7A-2a3lA:
undetectable		 3tj7A-2a3lA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 9 ALA A 680
GLY A 682
LEU A 685
ASN A 684
ILE A 700
 None
 1.47A 3wdmA-2a3lA:
undetectable		 3wdmA-2a3lA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 TYR A 261
THR A 326
TYR A 636
TYR A 633
 None
 1.50A 3wipC-2a3lA:
undetectable
3wipD-2a3lA:
undetectable		 3wipC-2a3lA:
14.63
3wipD-2a3lA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 TYR A 261
THR A 326
TYR A 636
TYR A 633
 None
 1.50A 3wipD-2a3lA:
undetectable
3wipE-2a3lA:
undetectable		 3wipD-2a3lA:
14.63
3wipE-2a3lA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 TYR A 261
THR A 326
TYR A 636
TYR A 633
 None
 1.45A 3wipA-2a3lA:
0.0
3wipE-2a3lA:
undetectable		 3wipA-2a3lA:
14.63
3wipE-2a3lA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 TYR A 631
CYH A 635
ILE A 545
ILE A 570
 None
 0.95A 4afgD-2a3lA:
undetectable
4afgE-2a3lA:
undetectable		 4afgD-2a3lA:
15.61
4afgE-2a3lA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 659
GLU A 662
GLU A 603
HIS A 681
SER A 708
ASP A 736
 ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
None
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
 0.94A 4aqlA-2a3lA:
11.4		 4aqlA-2a3lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 602
HIS A 391
HIS A 681
ASP A 736
TYR A 467
 None
ZN  A 840 ( 3.2A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.7A)
 1.41A 4bz6A-2a3lA:
undetectable
4bz6B-2a3lA:
undetectable		 4bz6A-2a3lA:
20.57
4bz6B-2a3lA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 HIS A 391
HIS A 393
HIS A 681
HIS A 659
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
 1.13A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 HIS A 659
HIS A 681
HIS A 393
HIS A 391
 ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
 1.04A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.30A 4gboA-2a3lA:
undetectable		 4gboA-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.40A 4gboB-2a3lA:
undetectable		 4gboB-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 SER A 562
PHE A 563
ASN A 565
ASP A 568
 None
 1.40A 4kcnB-2a3lA:
0.0		 4kcnB-2a3lA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 691
LEU A 694
LEU A 697
ALA A 698
LEU A 257
 None
 1.03A 4ltwA-2a3lA:
undetectable		 4ltwA-2a3lA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 11 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.41A 4lxzB-2a3lA:
undetectable		 4lxzB-2a3lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 LEU A 427
ILE A 420
ARG A 474
 None
 0.68A 4mk4B-2a3lA:
undetectable		 4mk4B-2a3lA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 681
HIS A 659
HIS A 393
ASP A 736
SER A 705
 CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
CF5  A 841 ( 2.5A)
None
 1.44A 4r88A-2a3lA:
14.3		 4r88A-2a3lA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 685
TYR A 695
ALA A 670
ILE A 339
 None
 0.80A 4y03A-2a3lA:
undetectable		 4y03A-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 685
TYR A 695
ALA A 670
ILE A 339
 None
 0.86A 4y03B-2a3lA:
undetectable		 4y03B-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 PHE A 490
ILE A 486
ASP A 483
 None
 0.68A 5cswA-2a3lA:
undetectable		 5cswA-2a3lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 PHE A 490
ILE A 486
ASP A 483
 None
 0.67A 5cswB-2a3lA:
undetectable		 5cswB-2a3lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 715
ASN A 709
PHE A 721
 None
 0.78A 5dsgB-2a3lA:
undetectable		 5dsgB-2a3lA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 682
HIS A 677
VAL A 632
CYH A 635
LEU A 599
 None
 0.94A 5ergB-2a3lA:
undetectable		 5ergB-2a3lA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 ASP A 737
HIS A 391
SER A 705
GLU A 662
 CF5  A 841 (-2.5A)
ZN  A 840 ( 3.2A)
None
CF5  A 841 (-2.6A)
 1.05A 5hfjC-2a3lA:
0.0		 5hfjC-2a3lA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 380
HIS A 786
ARG A 386
 PO4  A 842 (-2.8A)
PO4  A 842 ( 4.7A)
PO4  A 842 (-3.1A)
 0.98A 5iaoC-2a3lA:
undetectable		 5iaoC-2a3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 380
HIS A 786
ARG A 386
 PO4  A 842 (-2.8A)
PO4  A 842 ( 4.7A)
PO4  A 842 (-3.1A)
 1.01A 5iaoF-2a3lA:
undetectable		 5iaoF-2a3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 6 TYR A 633
ASP A 304
HIS A 308
TYR A 261
 None
 1.44A 5ov9A-2a3lA:
undetectable		 5ov9A-2a3lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 633
ASP A 304
HIS A 308
TYR A 261
 None
 1.44A 5ov9B-2a3lA:
1.7		 5ov9B-2a3lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 PRO A 269
LEU A 642
PHE A 263
LEU A 591
LEU A 574
 None
 1.24A 5tiwA-2a3lA:
undetectable		 5tiwA-2a3lA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.31A 5uizA-2a3lA:
undetectable		 5uizA-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 815
ARG A 771
ARG A 795
 None
 1.00A 5vcgA-2a3lA:
undetectable		 5vcgA-2a3lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 PRO A 738
VAL A 392
GLY A 492
VAL A 498
 None
 1.02A 6ak3B-2a3lA:
undetectable		 6ak3B-2a3lA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 PHE A 479
LEU A 429
VAL A 432
ARG A 476
ASP A 449
 None
 1.01A 6bxmA-2a3lA:
undetectable		 6bxmA-2a3lA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 GLU A 603
ASP A 389
HIS A 391
ALA A 680
LEU A 544
 None
None
ZN  A 840 ( 3.2A)
None
None
 0.98A 6ew0F-2a3lA:
undetectable		 6ew0F-2a3lA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 ASP A 737
ASP A 736
LYS A 466
GLN A 546
 CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
 1.31A 6g31A-2a3lA:
undetectable		 6g31A-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 ASP A 737
ASP A 736
LYS A 466
GLN A 546
 CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
 1.34A 6g31I-2a3lA:
undetectable		 6g31I-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 VAL A 837
TYR A 775
HIS A 781
GLU A 265
 None
 1.15A 6gneB-2a3lA:
2.4		 6gneB-2a3lA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.63A 6n91A-2a3lA:
20.5		 6n91A-2a3lA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.64A 6n91B-2a3lA:
20.8		 6n91B-2a3lA:
7.94