SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 12 ALA A  20
MET A 152
LEU A 185
ILE A 299
ARG A 304
 None
 1.10A 1dreA-2a3nA:
undetectable		 1dreA-2a3nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 8 PHE A  42
ILE A  37
PHE A  47
LEU A  70
 None
 0.91A 1fslA-2a3nA:
undetectable		 1fslA-2a3nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 7 VAL A 147
LEU A 223
SER A 225
LEU A 229
 None
 0.87A 1j8uA-2a3nA:
undetectable		 1j8uA-2a3nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 5 ALA A  77
ALA A  48
GLN A 116
VAL A 120
 None
 0.86A 2nyrB-2a3nA:
6.5		 2nyrB-2a3nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A  98
GLU A 105
ASP A 102
 None
 0.73A 2zthA-2a3nA:
2.5		 2zthA-2a3nA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A  98
GLU A 105
ASP A 102
 None
 0.71A 3bwmA-2a3nA:
2.0		 3bwmA-2a3nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A  98
GLU A 105
ASP A 102
 None
 0.67A 3bwyA-2a3nA:
undetectable		 3bwyA-2a3nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 10 LEU A 320
VAL A 312
MET A 217
GLY A 213
LEU A 316
 None
 1.02A 3ogpB-2a3nA:
undetectable		 3ogpB-2a3nA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		3 / 3 TYR A 208
MET A 209
ILE A 228
 None
 0.78A 4c8bB-2a3nA:
undetectable		 4c8bB-2a3nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 12 VAL A  94
LEU A 157
SER A  49
LEU A 131
VAL A 120
 None
 1.13A 4eckB-2a3nA:
undetectable		 4eckB-2a3nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 6 ARG A 319
ALA A 196
ASP A 318
LYS A 326
 None
 1.12A 4ot2A-2a3nA:
undetectable		 4ot2A-2a3nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 9 LEU A 131
GLY A 101
MET A  57
SER A  53
THR A  96
 None
 1.42A 4x3mA-2a3nA:
2.5		 4x3mA-2a3nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A  98
GLU A 105
ASP A 102
 None
 0.67A 4xudA-2a3nA:
2.0		 4xudA-2a3nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 6 GLU A 220
PRO A 309
GLY A 219
PHE A  63
 None
 1.31A 5jcnB-2a3nA:
undetectable		 5jcnB-2a3nA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 11 LEU A 259
GLU A 273
LEU A 253
ARG A 277
ALA A 279
 None
 1.10A 5o96A-2a3nA:
undetectable
5o96B-2a3nA:
undetectable		 5o96A-2a3nA:
21.25
5o96B-2a3nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 12 GLU A  75
VAL A  74
LEU A 131
PRO A  56
GLY A  52
 None
 1.26A 5syeB-2a3nA:
5.0		 5syeB-2a3nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		4 / 7 LEU A  97
VAL A 317
GLU A 220
SER A 313
 None
 1.16A 5umwA-2a3nA:
undetectable
5umwF-2a3nA:
undetectable		 5umwA-2a3nA:
14.04
5umwF-2a3nA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Salmonella
enterica) 		5 / 12 TYR A 171
ARG A  27
PHE A 168
TYR A 149
ILE A  23
 None
 1.32A 6mkeA-2a3nA:
undetectable
6mkeD-2a3nA:
undetectable		 6mkeA-2a3nA:
14.74
6mkeD-2a3nA:
14.74