SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		4 / 6 GLY A  82
ILE A 108
ILE A 143
ASP A  84
 None
 0.91A 3a7eA-2a4aA:
undetectable		 3a7eA-2a4aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		5 / 12 GLY A 175
GLY A 213
SER A 212
GLY A 245
ASP A  18
 None
 1.02A 3huoB-2a4aA:
undetectable		 3huoB-2a4aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		4 / 8 VAL A 211
VAL A  13
TYR A 224
ILE A 225
 None
 0.97A 3remA-2a4aA:
undetectable		 3remA-2a4aA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		4 / 8 VAL A 211
VAL A  13
TYR A 224
ILE A 225
 None
 0.96A 3remB-2a4aA:
undetectable		 3remB-2a4aA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		4 / 6 PHE A  69
ILE A  62
ARG A  32
VAL A  50
 None
 1.34A 4mk4B-2a4aA:
undetectable		 4mk4B-2a4aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		5 / 12 GLY A  82
ILE A 144
VAL A 162
ILE A 170
THR A 158
 None
 1.01A 4q5mA-2a4aA:
undetectable		 4q5mA-2a4aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Plasmodium
yoelii) 		5 / 11 ALA A  74
ASP A 168
VAL A 146
ILE A 144
ILE A 189
 None
 1.34A 5y80A-2a4aA:
undetectable		 5y80A-2a4aA:
13.62