SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2a4c CADHERIN-11
(Mus
musculus) 		4 / 7 ASP A  32
SER A  30
SER A  26
GLU A  87
 None
 1.33A 3bc9A-2a4cA:
4.6		 3bc9A-2a4cA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2a4c CADHERIN-11
(Mus
musculus) 		3 / 3 TYR A  37
ARG A  23
SER A  54
 None
 1.13A 4dr2I-2a4cA:
undetectable
4dr2J-2a4cA:
undetectable		 4dr2I-2a4cA:
21.43
4dr2J-2a4cA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2a4c CADHERIN-11
(Mus
musculus) 		3 / 3 ARG A  68
GLN A  70
GLU A  42
 None
 0.69A 4tvtA-2a4cA:
undetectable		 4tvtA-2a4cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2a4c CADHERIN-11
(Mus
musculus) 		4 / 6 ASP A  52
PRO A  18
THR A  60
VAL A  49
 None
 0.85A 4yoaA-2a4cA:
undetectable		 4yoaA-2a4cA:
16.04