SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 7 PRO A 129
ILE A 126
LEU A 141
TYR A 134
ILE A 162
 None
 1.49A 3p50D-2a4dA:
undetectable		 3p50D-2a4dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		4 / 8 MET A 164
ILE A 126
LEU A 195
VAL A 156
 None
 0.90A 3w1wA-2a4dA:
undetectable		 3w1wA-2a4dA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 9 LEU A 141
LYS A 142
VAL A 167
GLY A 172
LEU A 198
 None
 1.42A 4b3oA-2a4dA:
undetectable		 4b3oA-2a4dA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		3 / 3 SER A 108
MET A 125
ASP A 114
 None
 0.92A 4mm4B-2a4dA:
undetectable		 4mm4B-2a4dA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 9 LEU A 141
SER A 140
THR A 160
ILE A 162
ILE A 126
 None
 1.27A 6ef6A-2a4dA:
undetectable		 6ef6A-2a4dA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		4 / 5 VAL A  83
LYS A  84
ASN A  88
PRO A 147
 None
 1.31A 6fi4A-2a4dA:
undetectable
6fi4B-2a4dA:
undetectable		 6fi4A-2a4dA:
21.86
6fi4B-2a4dA:
17.86