SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2a4e CADHERIN-11
(Mus
musculus) 		5 / 12 GLY A 194
GLY A 139
ASP A  98
ASN A 140
ALA A 142
 None
None
CA  A 302 (-3.1A)
None
None
 1.08A 2bm9F-2a4eA:
undetectable		 2bm9F-2a4eA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2a4e CADHERIN-11
(Mus
musculus) 		4 / 7 GLY A 162
GLY A 190
GLN A 184
PHE A 106
 None
 0.98A 2qwxA-2a4eA:
undetectable
2qwxB-2a4eA:
undetectable		 2qwxA-2a4eA:
21.71
2qwxB-2a4eA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2a4e CADHERIN-11
(Mus
musculus) 		4 / 7 ASP A  32
SER A  30
SER A  26
GLU A  87
 None
 1.19A 3bc9A-2a4eA:
3.6		 3bc9A-2a4eA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 2a4e CADHERIN-11
(Mus
musculus) 		4 / 6 ASP A  79
ARG A  84
ILE A  28
SER A  30
 None
 1.39A 3ckzA-2a4eA:
undetectable		 3ckzA-2a4eA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2a4e CADHERIN-11
(Mus
musculus) 		4 / 8 ASP A 134
SER A 141
LEU A  63
ASP A  64
 CA  A 301 ( 3.3A)
None
None
CA  A 303 (-2.9A)
 1.07A 3m0wE-2a4eA:
undetectable
3m0wF-2a4eA:
undetectable
3m0wG-2a4eA:
undetectable
3m0wH-2a4eA:
undetectable		 3m0wE-2a4eA:
18.98
3m0wF-2a4eA:
18.98
3m0wG-2a4eA:
18.98
3m0wH-2a4eA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2a4e CADHERIN-11
(Mus
musculus) 		3 / 3 ARG A  68
GLN A  70
GLU A  42
 None
 0.78A 4tvtA-2a4eA:
undetectable		 4tvtA-2a4eA:
20.54