SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 7 PRO A 208
ALA A 266
PHE A 267
PHE A 263
 None
 1.15A 1lqtA-2a4mA:
undetectable		 1lqtA-2a4mA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 7 PRO A 208
ALA A 266
PHE A 267
PHE A 263
 None
 1.15A 1lquA-2a4mA:
undetectable		 1lquA-2a4mA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 LEU A  37
LEU A  40
ALA A  41
GLN A  45
LEU A 264
 None
 0.85A 1ya3C-2a4mA:
undetectable		 1ya3C-2a4mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 11 ARG A 203
GLY A  42
GLY A 169
GLN A 200
THR A  27
 None
 1.46A 2eimG-2a4mA:
0.0
2eimN-2a4mA:
0.0
2eimO-2a4mA:
0.0		 2eimG-2a4mA:
15.15
2eimN-2a4mA:
21.94
2eimO-2a4mA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 6 LEU A 303
MET A 240
MET A 238
LEU A 210
 None
 1.45A 2oz7A-2a4mA:
undetectable		 2oz7A-2a4mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 GLY A  38
GLY A  42
ARG A 206
ASN A 222
ALA A 223
 None
 1.20A 2vdvE-2a4mA:
undetectable		 2vdvE-2a4mA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 11 GLY A  38
GLY A  42
ARG A 206
ASN A 222
ALA A 223
 None
 1.20A 2vdvF-2a4mA:
undetectable		 2vdvF-2a4mA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		3 / 3 THR A 112
SER A 153
PHE A 161
 None
 0.50A 3d4sA-2a4mA:
undetectable		 3d4sA-2a4mA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.99A 3fi0A-2a4mA:
32.5		 3fi0A-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 8 ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.79A 3fi0B-2a4mA:
32.0		 3fi0B-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.96A 3fi0C-2a4mA:
32.6		 3fi0C-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.97A 3fi0D-2a4mA:
33.0		 3fi0D-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 7 ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.69A 3fi0E-2a4mA:
31.6		 3fi0E-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.92A 3fi0H-2a4mA:
32.5		 3fi0H-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 8 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.97A 3fi0I-2a4mA:
32.7		 3fi0I-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.99A 3fi0J-2a4mA:
32.9		 3fi0J-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.93A 3fi0K-2a4mA:
31.9		 3fi0K-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.94A 3fi0N-2a4mA:
32.8		 3fi0N-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 1.05A 3fi0O-2a4mA:
32.7		 3fi0O-2a4mA:
31.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 1.04A 3fi0R-2a4mA:
31.3		 3fi0R-2a4mA:
31.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 LEU A  40
VAL A  48
TYR A  87
GLY A  91
LEU A 226
 None
 1.28A 3mecA-2a4mA:
undetectable		 3mecA-2a4mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 LEU A  40
VAL A  48
TYR A  87
GLY A  91
LEU A 226
 None
 1.33A 3medA-2a4mA:
undetectable
3medB-2a4mA:
undetectable		 3medA-2a4mA:
18.96
3medB-2a4mA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 ASN A  46
PRO A  23
LEU A 165
GLN A 200
LEU A  26
 None
 1.46A 4ac0A-2a4mA:
undetectable		 4ac0A-2a4mA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 8 PHE A 261
VAL A 260
LEU A 286
HIS A 294
 None
 1.17A 4f5zA-2a4mA:
undetectable		 4f5zA-2a4mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 243
ARG A 254
ASP A 251
 None
 0.73A 4fp9A-2a4mA:
undetectable		 4fp9A-2a4mA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 6 PHE A 261
ASP A 288
LEU A 286
HIS A 246
 None
 1.25A 4paeA-2a4mA:
undetectable		 4paeA-2a4mA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		3 / 3 ASP A 270
VAL A 298
LEU A 264
 None
 0.54A 5e5jB-2a4mA:
undetectable		 5e5jB-2a4mA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 6 GLY A  33
THR A  32
VAL A  83
HIS A  36
 None
 1.11A 5ewuB-2a4mA:
undetectable		 5ewuB-2a4mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 6 GLY A  33
THR A  32
VAL A  83
HIS A  39
 None
 1.10A 5ewuB-2a4mA:
undetectable		 5ewuB-2a4mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 GLY A 227
LEU A  35
VAL A  83
ALA A  82
LEU A  85
 None
 0.87A 5kpcA-2a4mA:
undetectable		 5kpcA-2a4mA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.95A 5v0iA-2a4mA:
33.3		 5v0iA-2a4mA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 9 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.96A 5v0iB-2a4mA:
33.6		 5v0iB-2a4mA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		4 / 5 LEU A  59
PHE A  57
PHE A 161
LEU A 108
 None
 1.13A 5x1bP-2a4mA:
undetectable		 5x1bP-2a4mA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 ASP A  68
SER A 217
SER A 219
VAL A 130
TYR A 139
 None
 1.36A 6h7lA-2a4mA:
undetectable		 6h7lA-2a4mA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II
(Deinococcus
radiodurans) 		5 / 12 ASP A  68
SER A 217
SER A 219
VAL A 130
TYR A 139
 None
 1.36A 6h7lB-2a4mA:
undetectable		 6h7lB-2a4mA:
15.09