SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.62A 1h4oA-2a4vA:
20.2
1h4oB-2a4vA:
20.3		 1h4oA-2a4vA:
26.47
1h4oB-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.64A 1h4oB-2a4vA:
20.3		 1h4oB-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.64A 1h4oC-2a4vA:
20.1
1h4oD-2a4vA:
20.1		 1h4oC-2a4vA:
26.47
1h4oD-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.64A 1h4oD-2a4vA:
20.1		 1h4oD-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.65A 1h4oE-2a4vA:
20.1
1h4oF-2a4vA:
20.1		 1h4oE-2a4vA:
26.47
1h4oF-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.63A 1h4oF-2a4vA:
20.1		 1h4oF-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.62A 1h4oG-2a4vA:
20.0		 1h4oG-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.60A 1h4oH-2a4vA:
20.1		 1h4oH-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.61A 1hd2A-2a4vA:
20.2		 1hd2A-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.61A 1oc3A-2a4vA:
20.2		 1oc3A-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.61A 1oc3B-2a4vA:
19.8		 1oc3B-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		6 / 9 PRO A 100
THR A 104
PRO A 105
GLY A 106
SER A 107
ARG A 175
 None
 0.86A 1urmA-2a4vA:
20.1		 1urmA-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  75
ASN A  76
LEU A  84
ILE A  87
 None
 0.84A 1z95A-2a4vA:
undetectable		 1z95A-2a4vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  82
SER A  83
ILE A  87
LEU A 152
VAL A  94
 None
 0.98A 2nnhA-2a4vA:
undetectable		 2nnhA-2a4vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.69A 2v2gA-2a4vA:
18.2
2v2gB-2a4vA:
18.3		 2v2gA-2a4vA:
25.32
2v2gB-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.69A 2v2gA-2a4vA:
18.2
2v2gB-2a4vA:
18.3		 2v2gA-2a4vA:
25.32
2v2gB-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.69A 2v2gC-2a4vA:
18.2
2v2gD-2a4vA:
18.3		 2v2gC-2a4vA:
25.32
2v2gD-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.71A 2v2gC-2a4vA:
18.2
2v2gD-2a4vA:
18.3		 2v2gC-2a4vA:
25.32
2v2gD-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 8 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.62A 2v32A-2a4vA:
18.1
2v32B-2a4vA:
17.9		 2v32A-2a4vA:
25.32
2v32B-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 8 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.65A 2v32A-2a4vA:
18.1
2v32B-2a4vA:
17.9		 2v32A-2a4vA:
25.32
2v32B-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.61A 2v32C-2a4vA:
18.1
2v32D-2a4vA:
20.6		 2v32C-2a4vA:
25.32
2v32D-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 8 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.68A 2v32C-2a4vA:
18.1
2v32D-2a4vA:
20.6		 2v32C-2a4vA:
25.32
2v32D-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.61A 2v41A-2a4vA:
18.2
2v41B-2a4vA:
18.0		 2v41A-2a4vA:
25.32
2v41B-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.68A 2v41A-2a4vA:
18.2
2v41B-2a4vA:
18.0		 2v41A-2a4vA:
25.32
2v41B-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.66A 2v41C-2a4vA:
20.6
2v41D-2a4vA:
20.6		 2v41C-2a4vA:
25.32
2v41D-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.68A 2v41C-2a4vA:
20.6
2v41D-2a4vA:
20.6		 2v41C-2a4vA:
25.32
2v41D-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.64A 2v41E-2a4vA:
17.9
2v41F-2a4vA:
18.0		 2v41E-2a4vA:
25.32
2v41F-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.65A 2v41E-2a4vA:
17.9
2v41F-2a4vA:
18.0		 2v41E-2a4vA:
25.32
2v41F-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 100
THR A 104
PRO A 105
SER A 107
ARG A 175
 None
 0.61A 2v41G-2a4vA:
18.1
2v41H-2a4vA:
18.0		 2v41G-2a4vA:
25.32
2v41H-2a4vA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
 None
 0.60A 2vl2A-2a4vA:
20.2
2vl2C-2a4vA:
17.8		 2vl2A-2a4vA:
26.55
2vl2C-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 100
THR A 104
PRO A 105
GLY A 106
 None
 0.57A 2vl2B-2a4vA:
19.9		 2vl2B-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		3 / 3 SER A 137
GLN A 138
PHE A 141
 None
 0.57A 3g4lC-2a4vA:
undetectable		 3g4lC-2a4vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 133
ARG A 101
ALA A 102
 None
 0.80A 3mbgC-2a4vA:
undetectable		 3mbgC-2a4vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  75
ASN A  76
LEU A  84
ILE A  87
 None
 0.83A 4okwA-2a4vA:
undetectable		 4okwA-2a4vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  98
LEU A 130
SER A 131
LEU A 162
GLY A 161
 None
 1.07A 4otyA-2a4vA:
undetectable		 4otyA-2a4vA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  98
LEU A 130
SER A 131
LEU A 162
GLY A 161
 None
 1.04A 4otyB-2a4vA:
undetectable		 4otyB-2a4vA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  74
PHE A  96
ILE A  82
ILE A  87
 None
 1.02A 5dzk4-2a4vA:
undetectable
5dzkg-2a4vA:
undetectable
5dzkm-2a4vA:
undetectable
5dzkn-2a4vA:
undetectable		 5dzk4-2a4vA:
2.08
5dzkg-2a4vA:
19.46
5dzkm-2a4vA:
19.60
5dzkn-2a4vA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  82
LEU A 130
GLY A 129
PHE A 128
ALA A 132
 None
 1.03A 5x66A-2a4vA:
undetectable
5x66B-2a4vA:
undetectable		 5x66A-2a4vA:
18.49
5x66B-2a4vA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2a4v PEROXIREDOXIN DOT5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  82
LEU A 130
GLY A 129
PHE A 128
ALA A 132
 None
 0.95A 5x66F-2a4vA:
undetectable		 5x66F-2a4vA:
18.49