SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 133
LEU A 130
MET A  84
LEU A   9
THR A  95
 None
 0.98A 1a28A-2a5lA:
0.0		 1a28A-2a5lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 133
LEU A 130
MET A  84
LEU A   9
THR A  95
 None
 0.97A 1a28B-2a5lA:
undetectable		 1a28B-2a5lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 116
GLY A  15
HIS A  14
ALA A 166
THR A  17
 None
 1.17A 1gtnH-2a5lA:
undetectable
1gtnI-2a5lA:
undetectable		 1gtnH-2a5lA:
19.29
1gtnI-2a5lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  15
HIS A  14
ALA A 166
THR A  17
ALA A 116
 None
 1.15A 1gtnM-2a5lA:
undetectable
1gtnN-2a5lA:
undetectable		 1gtnM-2a5lA:
19.29
1gtnN-2a5lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 9 GLY A  15
HIS A  14
ALA A 166
THR A  17
ALA A 116
 None
 1.14A 1gtnQ-2a5lA:
undetectable
1gtnR-2a5lA:
undetectable		 1gtnQ-2a5lA:
19.29
1gtnR-2a5lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 110
PHE A 112
GLY A 161
ALA A 109
LEU A 189
 None
 1.10A 1mjqC-2a5lA:
undetectable
1mjqD-2a5lA:
undetectable		 1mjqC-2a5lA:
19.40
1mjqD-2a5lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 109
LEU A 189
ALA A 110
PHE A 112
GLY A 161
 None
 1.09A 1mjqG-2a5lA:
undetectable
1mjqH-2a5lA:
undetectable		 1mjqG-2a5lA:
19.40
1mjqH-2a5lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 110
PHE A 112
GLY A 161
ALA A 109
LEU A 189
 None
 1.09A 1mjqI-2a5lA:
undetectable
1mjqJ-2a5lA:
undetectable		 1mjqI-2a5lA:
19.40
1mjqJ-2a5lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 133
LEU A 130
MET A  84
LEU A   9
LEU A  88
 None
 1.02A 1sqnB-2a5lA:
undetectable		 1sqnB-2a5lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 169
GLU A 178
ARG A  22
 None
 0.86A 1wopA-2a5lA:
undetectable		 1wopA-2a5lA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 133
LEU A 130
MET A  84
LEU A   9
THR A  95
 None
 0.96A 1zucB-2a5lA:
undetectable		 1zucB-2a5lA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		4 / 8 ILE A   6
LYS A 187
GLN A  30
GLU A 191
 None
 1.09A 5dqyA-2a5lA:
undetectable		 5dqyA-2a5lA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 112
GLY A 161
THR A 158
GLN A 126
LEU A 181
 None
 1.09A 5kocB-2a5lA:
undetectable		 5kocB-2a5lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2a5l TRP REPRESSOR
BINDING PROTEIN WRBA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 142
GLY A 161
VAL A 140
ALA A 109
LEU A 141
 None
 0.97A 5kpcA-2a5lA:
undetectable		 5kpcA-2a5lA:
19.95