SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 8 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
 0.19A 1ekjA-2a5vA:
19.4
1ekjB-2a5vA:
19.3		 1ekjA-2a5vA:
29.49
1ekjB-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 8 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
 1.02A 1ekjA-2a5vA:
19.4
1ekjB-2a5vA:
19.3		 1ekjA-2a5vA:
29.49
1ekjB-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 8 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
 0.23A 1ekjA-2a5vA:
19.4
1ekjB-2a5vA:
19.3		 1ekjA-2a5vA:
29.49
1ekjB-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 7 CYH A  51
ASP A  53
HIS A 104
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
SCN  A 501 (-4.2A)
 0.18A 1ekjE-2a5vA:
19.1
1ekjF-2a5vA:
19.2		 1ekjE-2a5vA:
29.49
1ekjF-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 7 CYH A  51
ASP A  53
HIS A 104
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
SCN  A 501 (-4.2A)
 0.96A 1ekjE-2a5vA:
19.1
1ekjF-2a5vA:
19.2		 1ekjE-2a5vA:
29.49
1ekjF-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 8 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
 0.16A 1ekjG-2a5vA:
19.3
1ekjH-2a5vA:
19.3		 1ekjG-2a5vA:
29.49
1ekjH-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 8 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
 1.00A 1ekjG-2a5vA:
19.3
1ekjH-2a5vA:
19.3		 1ekjG-2a5vA:
29.49
1ekjH-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 6 CYH A  51
ASP A  53
HIS A 104
CYH A 107
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
 0.16A 1ekjG-2a5vA:
19.3
1ekjH-2a5vA:
19.3		 1ekjG-2a5vA:
29.49
1ekjH-2a5vA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.51A 1rjoA-2a5vA:
undetectable		 1rjoA-2a5vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.47A 1rkyA-2a5vA:
undetectable		 1rkyA-2a5vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  61
GLY A  16
PHE A  62
VAL A  21
ALA A  22
 None
 1.16A 1tsnA-2a5vA:
undetectable		 1tsnA-2a5vA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.39A 1v54A-2a5vA:
undetectable		 1v54A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 1v54N-2a5vA:
undetectable		 1v54N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 1v55A-2a5vA:
undetectable		 1v55A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 1v55N-2a5vA:
undetectable		 1v55N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.61A 1w2zA-2a5vA:
undetectable		 1w2zA-2a5vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.58A 1w2zB-2a5vA:
undetectable		 1w2zB-2a5vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.56A 1w2zC-2a5vA:
undetectable		 1w2zC-2a5vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.54A 1w2zD-2a5vA:
undetectable		 1w2zD-2a5vA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 200
ILE A  48
ILE A 171
MET A 165
 None
 0.90A 1zgyA-2a5vA:
undetectable		 1zgyA-2a5vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 167
LEU A  84
VAL A  91
VAL A 101
 None
 0.90A 2bdmA-2a5vA:
undetectable		 2bdmA-2a5vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.38A 2dyrA-2a5vA:
undetectable		 2dyrA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 2dyrN-2a5vA:
undetectable		 2dyrN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 2dysA-2a5vA:
undetectable		 2dysA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 2dysN-2a5vA:
undetectable		 2dysN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.37A 2eijA-2a5vA:
undetectable		 2eijA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.39A 2eijN-2a5vA:
undetectable		 2eijN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.35A 2eikA-2a5vA:
undetectable		 2eikA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 2eikN-2a5vA:
undetectable		 2eikN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.39A 2eilA-2a5vA:
undetectable		 2eilA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 2eilN-2a5vA:
undetectable		 2eilN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 2eimA-2a5vA:
undetectable		 2eimA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 2eimN-2a5vA:
undetectable		 2eimN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 2einA-2a5vA:
undetectable		 2einA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 2einN-2a5vA:
undetectable		 2einN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.52A 2oqeA-2a5vA:
undetectable		 2oqeA-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.52A 2oqeB-2a5vA:
undetectable		 2oqeB-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.51A 2oqeC-2a5vA:
undetectable		 2oqeC-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.50A 2oqeD-2a5vA:
undetectable		 2oqeD-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.52A 2oqeF-2a5vA:
undetectable		 2oqeF-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  13
LEU A  98
ILE A  61
VAL A  91
VAL A  71
 None
 1.17A 2pnjB-2a5vA:
3.5		 2pnjB-2a5vA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.51A 2w0qA-2a5vA:
undetectable		 2w0qA-2a5vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.54A 2w0qB-2a5vA:
undetectable		 2w0qB-2a5vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.48A 2y69A-2a5vA:
undetectable		 2y69A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 2y69N-2a5vA:
undetectable		 2y69N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.56A 2zxwA-2a5vA:
undetectable		 2zxwA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.50A 2zxwN-2a5vA:
undetectable		 2zxwN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 3abkA-2a5vA:
undetectable		 3abkA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 3abkN-2a5vA:
undetectable		 3abkN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 3ablA-2a5vA:
undetectable		 3ablA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.52A 3ablN-2a5vA:
undetectable		 3ablN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.48A 3abmA-2a5vA:
undetectable		 3abmA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 3abmN-2a5vA:
undetectable		 3abmN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 3ag1A-2a5vA:
undetectable		 3ag1A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 3ag1N-2a5vA:
undetectable		 3ag1N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 3ag2A-2a5vA:
undetectable		 3ag2A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.43A 3ag2N-2a5vA:
undetectable		 3ag2N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.43A 3ag3A-2a5vA:
undetectable		 3ag3A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.46A 3ag3N-2a5vA:
undetectable		 3ag3N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.38A 3ag4A-2a5vA:
undetectable		 3ag4A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.34A 3ag4N-2a5vA:
undetectable		 3ag4N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 3asnA-2a5vA:
undetectable		 3asnA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 3asnN-2a5vA:
undetectable		 3asnN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 3asoA-2a5vA:
undetectable		 3asoA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.43A 3asoN-2a5vA:
undetectable		 3asoN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.72A 3bvdA-2a5vA:
undetectable		 3bvdA-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  72
ARG A 167
ILE A 182
THR A  74
 None
 1.27A 3cl9A-2a5vA:
undetectable		 3cl9A-2a5vA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 3dtuA-2a5vA:
undetectable		 3dtuA-2a5vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 3dtuC-2a5vA:
undetectable		 3dtuC-2a5vA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 108
GLY A 103
GLY A  76
PHE A  20
ASP A  53
 SCN  A 501 (-4.2A)
None
ZN  A 401 ( 4.4A)
None
SCN  A 501 (-4.0A)
 0.90A 3elwA-2a5vA:
undetectable		 3elwA-2a5vA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.48A 3hiiA-2a5vA:
undetectable		 3hiiA-2a5vA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.48A 3hiiB-2a5vA:
undetectable		 3hiiB-2a5vA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 10 THR A 160
VAL A 101
ILE A  99
ILE A  87
SER A  86
 None
 1.34A 3kpbD-2a5vA:
undetectable		 3kpbD-2a5vA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.57A 3s33A-2a5vA:
undetectable		 3s33A-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.63A 3s38A-2a5vA:
undetectable		 3s38A-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.53A 3s39A-2a5vA:
undetectable		 3s39A-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.65A 3s3aA-2a5vA:
undetectable		 3s3aA-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.55A 3s3bA-2a5vA:
undetectable		 3s3bA-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.60A 3s3cA-2a5vA:
undetectable		 3s3cA-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.56A 3s3dA-2a5vA:
undetectable		 3s3dA-2a5vA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		7 / 10 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
ALA A 109
ALA A 112
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
SCN  A 501 ( 4.4A)
None
 0.27A 3ucjA-2a5vA:
19.1		 3ucjA-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 10 CYH A  51
HIS A 104
CYH A 107
ALA A 109
ALA A 113
 ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 ( 4.4A)
None
 1.15A 3ucjA-2a5vA:
19.1		 3ucjA-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 GLN A  42
PHE A  70
TYR A  89
 None
 0.28A 3ucjB-2a5vA:
19.7		 3ucjB-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 GLN A  42
PHE A  70
TYR A  89
 None
 0.29A 3ucjA-2a5vA:
19.1		 3ucjA-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		7 / 10 CYH A  51
ASP A  53
HIS A 104
CYH A 107
GLY A 108
ALA A 109
ALA A 112
 ZN  A 401 ( 2.3A)
SCN  A 501 (-4.0A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 (-4.2A)
SCN  A 501 ( 4.4A)
None
 0.27A 3ucjB-2a5vA:
19.8		 3ucjB-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 10 CYH A  51
HIS A 104
CYH A 107
ALA A 109
ALA A 113
 ZN  A 401 ( 2.3A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 2.3A)
SCN  A 501 ( 4.4A)
None
 1.15A 3ucjB-2a5vA:
19.8		 3ucjB-2a5vA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  91
ILE A 175
ILE A 182
VAL A 101
ILE A 163
 None
 1.27A 3w67D-2a5vA:
undetectable		 3w67D-2a5vA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.46A 3wg7A-2a5vA:
undetectable		 3wg7A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.48A 3wg7N-2a5vA:
undetectable		 3wg7N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 3x2qA-2a5vA:
undetectable		 3x2qA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 3x2qN-2a5vA:
undetectable		 3x2qN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 104
GLU A 153
ASN A 111
 ZN  A 401 ( 3.3A)
None
None
 1.01A 4bupB-2a5vA:
undetectable		 4bupB-2a5vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  61
GLY A  16
PHE A  62
VAL A  21
ALA A  22
 None
 1.17A 4foxD-2a5vA:
undetectable		 4foxD-2a5vA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  61
GLY A  16
PHE A  62
VAL A  21
ALA A  22
 None
 1.13A 4fqsA-2a5vA:
0.0		 4fqsA-2a5vA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  61
GLY A  16
PHE A  62
VAL A  21
ALA A  22
 None
 1.13A 4fqsB-2a5vA:
0.0		 4fqsB-2a5vA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  16
ASP A  68
PRO A  28
HIS A  34
 None
 1.14A 4lajA-2a5vA:
undetectable
4lajB-2a5vA:
undetectable		 4lajA-2a5vA:
21.11
4lajB-2a5vA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 180
ARG A 174
SER A 168
LEU A 164
ILE A 182
 None
 1.25A 4ubsA-2a5vA:
undetectable		 4ubsA-2a5vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 110
LEU A 114
VAL A 138
 None
 0.61A 4wq4A-2a5vA:
undetectable		 4wq4A-2a5vA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.43A 5b1aA-2a5vA:
undetectable		 5b1aA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.46A 5b1aN-2a5vA:
undetectable		 5b1aN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.40A 5b1bA-2a5vA:
undetectable		 5b1bA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 5b1bN-2a5vA:
undetectable		 5b1bN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.39A 5b3sA-2a5vA:
undetectable		 5b3sA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 5b3sN-2a5vA:
undetectable		 5b3sN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 ASN A   3
ASP A  68
GLY A  67
 None
 0.63A 5fctB-2a5vA:
undetectable		 5fctB-2a5vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 5iy5A-2a5vA:
undetectable		 5iy5A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 5iy5N-2a5vA:
undetectable		 5iy5N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 153
HIS A 156
VAL A 110
 None
 0.87A 5trqB-2a5vA:
undetectable		 5trqB-2a5vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 5w97a-2a5vA:
undetectable		 5w97a-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 5waua-2a5vA:
undetectable		 5waua-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 104
GLU A 153
ASN A 111
 ZN  A 401 ( 3.3A)
None
None
 0.96A 5wbvA-2a5vA:
undetectable		 5wbvA-2a5vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 104
GLU A 153
ASN A 111
 ZN  A 401 ( 3.3A)
None
None
 0.96A 5wbvB-2a5vA:
undetectable		 5wbvB-2a5vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 5x19A-2a5vA:
undetectable		 5x19A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 5x19N-2a5vA:
undetectable		 5x19N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.50A 5x1bA-2a5vA:
undetectable		 5x1bA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 5x1bN-2a5vA:
undetectable		 5x1bN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 5x1fA-2a5vA:
undetectable		 5x1fA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.41A 5x1fN-2a5vA:
undetectable		 5x1fN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 5xdqA-2a5vA:
undetectable		 5xdqA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 5xdqN-2a5vA:
undetectable		 5xdqN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 5xdxA-2a5vA:
undetectable		 5xdxA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.43A 5xdxN-2a5vA:
undetectable		 5xdxN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 5z84A-2a5vA:
undetectable		 5z84A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.50A 5z84N-2a5vA:
undetectable		 5z84N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 5z85A-2a5vA:
undetectable		 5z85A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.50A 5z85N-2a5vA:
undetectable		 5z85N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 5z86A-2a5vA:
undetectable		 5z86A-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.52A 5z86N-2a5vA:
undetectable		 5z86N-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 5zcoA-2a5vA:
undetectable		 5zcoA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.42A 5zcoN-2a5vA:
undetectable		 5zcoN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.46A 5zcpA-2a5vA:
undetectable		 5zcpA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 5zcpN-2a5vA:
undetectable		 5zcpN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.44A 5zcqA-2a5vA:
undetectable		 5zcqA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 5zcqN-2a5vA:
undetectable		 5zcqN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.71A 6giqa-2a5vA:
undetectable		 6giqa-2a5vA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 6hu9a-2a5vA:
undetectable		 6hu9a-2a5vA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.54A 6hu9m-2a5vA:
undetectable		 6hu9m-2a5vA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.48A 6nknA-2a5vA:
undetectable		 6nknA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.48A 6nknN-2a5vA:
undetectable		 6nknN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.47A 6nmfA-2a5vA:
undetectable		 6nmfA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.45A 6nmfN-2a5vA:
undetectable		 6nmfN-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.52A 6nmpA-2a5vA:
undetectable		 6nmpA-2a5vA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.49A 6nmpN-2a5vA:
undetectable		 6nmpN-2a5vA:
17.81