SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		4 / 8 GLU A  75
ARG A  77
LEU A  78
GLU A 112
 None
 1.01A 1cmaA-2a5yA:
undetectable
1cmaB-2a5yA:
undetectable		 1cmaA-2a5yA:
17.20
1cmaB-2a5yA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		4 / 6 ASN A  71
ASP A  72
TRP A 221
TYR A 168
 None
 1.34A 1hpkA-2a5yA:
undetectable		 1hpkA-2a5yA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 12 GLU A 112
ASP A  86
VAL A 109
PHE A  88
LEU A 198
 None
 1.34A 1nw3A-2a5yA:
undetectable		 1nw3A-2a5yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		3 / 3 PHE A  88
TYR A 149
TYR A 201
 None
 0.89A 1x70B-2a5yA:
undetectable		 1x70B-2a5yA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		4 / 8 VAL A 141
LEU A 139
VAL A 181
VAL A 153
 None
 1.00A 2bdmA-2a5yA:
1.4		 2bdmA-2a5yA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 11 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.17A 3v3nA-2a5yA:
undetectable		 3v3nA-2a5yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 11 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.17A 3v3nD-2a5yA:
undetectable		 3v3nD-2a5yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 12 MET A 185
ILE A 144
LEU A 198
VAL A 156
LEU A 148
 None
 1.36A 4m11C-2a5yA:
undetectable		 4m11C-2a5yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 9 THR A 202
ALA A 102
GLY A 178
GLY A 179
ALA A 182
 None
 1.07A 4qvmK-2a5yA:
undetectable
4qvmL-2a5yA:
undetectable		 4qvmK-2a5yA:
19.91
4qvmL-2a5yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 10 THR A 202
ALA A 102
GLY A 178
GLY A 179
ALA A 182
 None
 1.06A 4qw1Y-2a5yA:
undetectable
4qw1Z-2a5yA:
undetectable		 4qw1Y-2a5yA:
20.35
4qw1Z-2a5yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 12 THR A 202
THR A  89
ALA A 102
GLY A 178
ALA A 182
 None
 1.17A 5lf7V-2a5yA:
undetectable
5lf7b-2a5yA:
undetectable		 5lf7V-2a5yA:
19.11
5lf7b-2a5yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		5 / 12 THR A 202
THR A  89
ALA A 102
GLY A 178
ALA A 182
 None
 1.16A 5lf7H-2a5yA:
undetectable
5lf7N-2a5yA:
undetectable		 5lf7H-2a5yA:
19.11
5lf7N-2a5yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2a5y APOPTOSIS REGULATOR
CED-9
(Caenorhabditis
elegans) 		4 / 6 TRP A 221
ILE A  80
GLY A  82
GLU A  81
 None
 0.96A 6gqiA-2a5yA:
undetectable		 6gqiA-2a5yA:
17.16