SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 12 ALA A 105
VAL A 122
ILE A 138
GLY A 139
ILE A 249
 None
 0.88A 2avsA-2a5zA:
undetectable		 2avsA-2a5zA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		4 / 7 TYR A  53
MET A  56
ASP A 247
SER A  83
 None
None
MG  A 701 (-3.2A)
None
 1.01A 3lslA-2a5zA:
undetectable
3lslD-2a5zA:
undetectable		 3lslA-2a5zA:
23.67
3lslD-2a5zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		4 / 7 SER A  83
TYR A  53
MET A  56
ASP A 247
 None
None
None
MG  A 701 (-3.2A)
 1.08A 3lslA-2a5zA:
undetectable
3lslD-2a5zA:
undetectable		 3lslA-2a5zA:
23.67
3lslD-2a5zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 11 PHE A 251
VAL A 122
ILE A 228
ALA A 105
THR A 141
 None
 1.12A 3mdtB-2a5zA:
undetectable		 3mdtB-2a5zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		3 / 3 THR A 213
SER A 214
ARG A 196
 None
 0.65A 3phnA-2a5zA:
undetectable		 3phnA-2a5zA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 12 PHE A 124
LEU A 179
LEU A 201
LEU A 209
TYR A 177
 None
 1.28A 4xumA-2a5zA:
undetectable		 4xumA-2a5zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 11 PRO A 127
GLU A 156
GLY A 158
SER A 245
ARG A 150
 None
 0.83A 5o96A-2a5zA:
undetectable
5o96B-2a5zA:
undetectable		 5o96A-2a5zA:
19.57
5o96B-2a5zA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 12 HIS A 227
THR A 141
LEU A  71
LEU A 104
GLY A 144
 None
 1.47A 6f3nA-2a5zA:
undetectable		 6f3nA-2a5zA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 12 HIS A 227
THR A 141
LEU A  71
LEU A 104
GLY A 144
 None
 1.45A 6f3nC-2a5zA:
undetectable		 6f3nC-2a5zA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 2a5z HYPOTHETICAL PROTEIN
SO2946
(Shewanella
oneidensis) 		5 / 12 HIS A 227
THR A 141
LEU A  71
LEU A 104
GLY A 144
 None
 1.48A 6f3nD-2a5zA:
undetectable		 6f3nD-2a5zA:
23.11