SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 2a61 TRANSCRIPTIONAL
REGULATOR TM0710
(Thermotoga
maritima) 		5 / 12 GLY A  52
LEU A  54
GLU A  53
ALA A  89
ASP A  83
 None
 1.08A 3tbgB-2a61A:
undetectable		 3tbgB-2a61A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 2a61 TRANSCRIPTIONAL
REGULATOR TM0710
(Thermotoga
maritima) 		5 / 12 GLY A  52
LEU A  54
GLU A  53
ALA A  89
ASP A  83
 None
 1.04A 3tbgD-2a61A:
undetectable		 3tbgD-2a61A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2a61 TRANSCRIPTIONAL
REGULATOR TM0710
(Thermotoga
maritima) 		3 / 3 PHE A  91
VAL A  65
ILE A  39
 None
 0.59A 4emaA-2a61A:
undetectable		 4emaA-2a61A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2a61 TRANSCRIPTIONAL
REGULATOR TM0710
(Thermotoga
maritima) 		4 / 5 LEU A  54
VAL A  69
GLU A  73
LEU A  92
 None
 0.98A 5xooB-2a61A:
undetectable		 5xooB-2a61A:
24.14