SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a62 CADHERIN-8
(Mus
musculus) 		4 / 7 ILE A  94
LEU A  73
PHE A  92
ARG A  23
 None
 1.05A 2zxwN-2a62A:
undetectable
2zxwW-2a62A:
undetectable		 2zxwN-2a62A:
20.25
2zxwW-2a62A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2a62 CADHERIN-8
(Mus
musculus) 		4 / 7 VAL A  96
ASP A 101
TYR A  71
ILE A  47
 None
CA  A 325 ( 2.7A)
None
None
 1.00A 3avpA-2a62A:
undetectable		 3avpA-2a62A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2a62 CADHERIN-8
(Mus
musculus) 		5 / 10 ILE A 319
ILE A 234
GLY A 231
LEU A 262
ARG A 279
 None
 1.40A 3elzB-2a62A:
undetectable		 3elzB-2a62A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_A_TOYA301_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 2a62 CADHERIN-8
(Mus
musculus) 		5 / 9 GLU A  67
GLU A  12
ASP A  64
GLU A  11
ASP A 134
 None
CA  A 325 (-3.3A)
CA  A 325 (-3.0A)
CA  A 325 ( 2.5A)
CA  A 324 ( 3.1A)
 1.46A 4ebkA-2a62A:
0.0
4ebkB-2a62A:
0.0		 4ebkA-2a62A:
21.99
4ebkB-2a62A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_B_TOYB302_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 2a62 CADHERIN-8
(Mus
musculus) 		5 / 9 ASP A 134
GLU A  67
GLU A  12
ASP A  64
GLU A  11
 CA  A 324 ( 3.1A)
None
CA  A 325 (-3.3A)
CA  A 325 (-3.0A)
CA  A 325 ( 2.5A)
 1.50A 4ebkA-2a62A:
0.0
4ebkB-2a62A:
0.0		 4ebkA-2a62A:
21.99
4ebkB-2a62A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2a62 CADHERIN-8
(Mus
musculus) 		4 / 5 ASN A 247
SER A 307
ASP A 172
GLU A 117
 None
None
CA  A 328 ( 4.9A)
CA  A 328 ( 2.6A)
 1.46A 4zjlA-2a62A:
0.0		 4zjlA-2a62A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2a62 CADHERIN-8
(Mus
musculus) 		3 / 3 ARG A 236
LYS A 238
TYR A 252
 None
 1.03A 6gnaA-2a62A:
undetectable		 6gnaA-2a62A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2a62 CADHERIN-8
(Mus
musculus) 		3 / 3 ARG A 236
LYS A 238
TYR A 252
 None
 1.03A 6gnbA-2a62A:
undetectable		 6gnbA-2a62A:
22.71