SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 5 GLU F 355
THR F 346
LEU F 349
LEU F 350
 None
 1.21A 1u18B-2a6eF:
undetectable		 1u18B-2a6eF:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 6 ARG F 256
LEU F 308
GLN F 312
GLU F 313
 None
 1.09A 2fcnA-2a6eF:
undetectable
2fcnB-2a6eF:
undetectable		 2fcnA-2a6eF:
13.54
2fcnB-2a6eF:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 6 ILE F 221
PHE F 235
ALA F 223
ASN F 191
 None
 1.11A 3pgyA-2a6eF:
undetectable
3pgyB-2a6eF:
undetectable		 3pgyA-2a6eF:
22.74
3pgyB-2a6eF:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 8 GLU F  98
GLU F  87
GLN F  90
GLY F  89
 None
 0.85A 4f93B-2a6eF:
undetectable		 4f93B-2a6eF:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 4 LEU F 122
ARG F 128
ILE F 127
ILE F 113
 None
 1.36A 5dzk2-2a6eF:
undetectable
5dzkM-2a6eF:
undetectable
5dzkN-2a6eF:
undetectable		 5dzk2-2a6eF:
3.85
5dzkM-2a6eF:
20.10
5dzkN-2a6eF:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 4 ILE F 127
ILE F 113
ARG F 128
LEU F 122
 None
 1.32A 5dzkh-2a6eF:
undetectable
5dzkn-2a6eF:
undetectable
5dzkv-2a6eF:
undetectable		 5dzkh-2a6eF:
20.10
5dzkn-2a6eF:
20.10
5dzkv-2a6eF:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		5 / 9 LEU F 220
ILE F 198
ILE F  88
GLU F  87
GLU F  99
 None
 1.41A 5igzA-2a6eF:
undetectable		 5igzA-2a6eF:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		4 / 6 LYS F 230
ARG F 104
GLU F 107
ALA F 103
 None
 0.80A 6an0A-2a6eF:
undetectable		 6an0A-2a6eF:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		3 / 3 ARG F 231
LYS F 226
TYR F 238
 None
 1.04A 6gnaA-2a6eF:
undetectable		 6gnaA-2a6eF:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2a6e RNA POLYMERASE SIGMA
FACTOR RPOD
(Thermus
thermophilus) 		3 / 3 ARG F 231
LYS F 226
TYR F 238
 None
 1.04A 6gnbA-2a6eF:
undetectable		 6gnbA-2a6eF:
18.93