SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		5 / 9 THR A  83
LEU A  51
VAL A  53
ILE A  55
ILE A  21
 None
 1.07A 1gebA-2a6oA:
undetectable		 1gebA-2a6oA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		4 / 5 ILE A  67
ALA A  84
MET A  58
PHE A  80
 None
 1.08A 4dc3B-2a6oA:
undetectable		 4dc3B-2a6oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		4 / 7 ILE A  91
LEU A 106
LEU A  40
ILE A  44
 None
 0.78A 4rmjA-2a6oA:
undetectable		 4rmjA-2a6oA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		3 / 3 LYS A  82
LEU A 106
ILE A  43
 None
 0.79A 5kc4A-2a6oA:
undetectable		 5kc4A-2a6oA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		5 / 10 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A 113
 None
 1.23A 6ebpB-2a6oA:
undetectable		 6ebpB-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		5 / 10 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A 113
 None
 1.21A 6ebpC-2a6oA:
undetectable		 6ebpC-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		6 / 10 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
ILE A 113
 None
 1.18A 6ebpD-2a6oA:
undetectable		 6ebpD-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		6 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
ILE A 113
 None
 1.21A 6ebzA-2a6oA:
undetectable		 6ebzA-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		6 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
ILE A 113
 None
 1.20A 6ebzB-2a6oA:
undetectable		 6ebzB-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		6 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
ILE A 113
 None
 1.20A 6ebzC-2a6oA:
undetectable		 6ebzC-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		6 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
ILE A 113
 None
 1.20A 6ebzD-2a6oA:
undetectable		 6ebzD-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		5 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
 None
 1.03A 6gp2A-2a6oA:
undetectable		 6gp2A-2a6oA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2a6o ISHP608 TRANSPOSASE
(Helicobacter
pylori) 		5 / 11 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
 None
 1.04A 6gp2B-2a6oA:
undetectable		 6gp2B-2a6oA:
19.74