SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 117
ALA A 115
SER A  90
 None
 0.68A 1errB-2a6pA:
undetectable		 1errB-2a6pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  83
TRP A 109
PHE A 144
LEU A  10
VAL A 108
 None
 1.34A 2w8yA-2a6pA:
undetectable		 2w8yA-2a6pA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 119
SER A 167
LEU A  10
ALA A 153
 None
 0.89A 3kk6B-2a6pA:
undetectable		 3kk6B-2a6pA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  43
GLY A  48
LEU A  47
LEU A  11
 None
 0.87A 4po0A-2a6pA:
undetectable		 4po0A-2a6pA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		3 / 4 ARG A 168
GLY A 166
GLU A 165
 None
 0.57A 4z2dB-2a6pA:
undetectable
4z2dC-2a6pA:
undetectable		 4z2dB-2a6pA:
18.85
4z2dC-2a6pA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 136
ILE A  58
VAL A  57
ARG A 140
 None
 1.22A 5kkzC-2a6pA:
undetectable
5kkzE-2a6pA:
undetectable		 5kkzC-2a6pA:
24.26
5kkzE-2a6pA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  58
VAL A  57
ARG A 140
HIS A 136
 None
 1.21A 5kkzK-2a6pA:
undetectable
5kkzQ-2a6pA:
undetectable		 5kkzK-2a6pA:
18.88
5kkzQ-2a6pA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 136
ILE A  58
VAL A  57
ARG A 140
 None
 1.26A 5kkzM-2a6pA:
undetectable
5kkzO-2a6pA:
undetectable		 5kkzM-2a6pA:
24.26
5kkzO-2a6pA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  83
LEU A 134
ALA A 133
LEU A   8
 None
 0.88A 5y7pC-2a6pA:
undetectable		 5y7pC-2a6pA:
20.65