SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 121
ARG A 119
ILE A 141
 None
 0.74A 1a4gB-2a6vA:
undetectable		 1a4gB-2a6vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 211
ASN A 206
GLY A  55
GLY A  79
SER A  77
 None
 1.21A 1q8jB-2a6vA:
undetectable		 1q8jB-2a6vA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 8 SER A 196
PHE A 192
LEU A 132
LEU A 175
LEU A 165
 None
 1.49A 2bfpB-2a6vA:
undetectable		 2bfpB-2a6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 8 SER A 196
PHE A 192
LEU A 132
LEU A 175
LEU A 165
 None
 1.39A 2bfpC-2a6vA:
undetectable		 2bfpC-2a6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 204
GLY A 105
THR A 101
THR A  84
PHE A 213
 None
 0.93A 2y7hC-2a6vA:
undetectable		 2y7hC-2a6vA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 175
LEU A 177
MET A 193
GLY A 113
LEU A 132
 None
 1.26A 3hm1B-2a6vA:
undetectable		 3hm1B-2a6vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 11 THR A  48
THR A  53
SER A  56
ALA A 204
THR A 202
 None
 1.49A 4qvyV-2a6vA:
undetectable
4qvyb-2a6vA:
0.0		 4qvyV-2a6vA:
21.37
4qvyb-2a6vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 11 THR A  48
THR A  53
SER A  56
ALA A 204
THR A 202
 None
 1.49A 4qvyH-2a6vA:
undetectable
4qvyN-2a6vA:
0.0		 4qvyH-2a6vA:
21.37
4qvyN-2a6vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  92
ARG A 199
ILE A 200
PHE A 198
 None
 1.22A 5kirB-2a6vA:
undetectable		 5kirB-2a6vA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 11 THR A  48
THR A  53
SER A  56
ALA A 204
THR A 202
 None
 1.47A 5l5fV-2a6vA:
undetectable
5l5fb-2a6vA:
undetectable		 5l5fV-2a6vA:
21.37
5l5fb-2a6vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 11 THR A  48
THR A  53
SER A  56
ALA A 204
THR A 202
 None
 1.48A 5l5fH-2a6vA:
undetectable
5l5fN-2a6vA:
undetectable		 5l5fH-2a6vA:
21.37
5l5fN-2a6vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 106
PHE A 192
MET A 193
LEU A 132
PHE A 111
 None
 1.18A 5nknA-2a6vA:
0.0		 5nknA-2a6vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 105
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.15A 6exiA-2a6vA:
undetectable		 6exiA-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 106
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.18A 6exiA-2a6vA:
undetectable		 6exiA-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 105
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.11A 6exiB-2a6vA:
undetectable		 6exiB-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 106
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.17A 6exiB-2a6vA:
undetectable		 6exiB-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 105
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.13A 6exiC-2a6vA:
undetectable
6exiD-2a6vA:
undetectable		 6exiC-2a6vA:
17.90
6exiD-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 106
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.16A 6exiC-2a6vA:
undetectable
6exiD-2a6vA:
undetectable		 6exiC-2a6vA:
17.90
6exiD-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 105
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.16A 6exiC-2a6vA:
undetectable
6exiD-2a6vA:
undetectable		 6exiC-2a6vA:
17.90
6exiD-2a6vA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a6v EMP46P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 106
VAL A  38
ASP A  36
THR A 202
ILE A 215
 None
 1.16A 6exiC-2a6vA:
undetectable
6exiD-2a6vA:
undetectable		 6exiC-2a6vA:
17.90
6exiD-2a6vA:
17.90