SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 112
THR A 246
PHE A 148
PHE A 186
 None
 1.03A 2qx4A-2a6yA:
undetectable
2qx4B-2a6yA:
undetectable		 2qx4A-2a6yA:
19.62
2qx4B-2a6yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 180
ILE A 164
LEU A 115
GLY A 129
ALA A 149
 None
 0.89A 2xf3A-2a6yA:
undetectable		 2xf3A-2a6yA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		5 / 8 VAL A  27
GLY A  34
THR A  33
GLU A  35
ALA A  37
 None
 1.37A 3aruA-2a6yA:
undetectable		 3aruA-2a6yA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 131
ASP A 133
ILE A 245
GLY A 134
TYR A 110
 None
 1.34A 3hgiA-2a6yA:
undetectable		 3hgiA-2a6yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 127
VAL A 117
PHE A  74
VAL A 180
 None
 0.94A 3soaA-2a6yA:
undetectable		 3soaA-2a6yA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 192
ASP A 172
ASP A 230
 None
 0.87A 4kicB-2a6yA:
undetectable		 4kicB-2a6yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  99
ASP A  94
VAL A 108
ASP A 100
 SO4  A 256 (-3.7A)
SO4  A 256 (-2.9A)
None
None
 1.36A 4xqeA-2a6yA:
undetectable		 4xqeA-2a6yA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  99
ASP A  94
VAL A 108
ASP A 100
 SO4  A 256 (-3.7A)
SO4  A 256 (-2.9A)
None
None
 1.40A 4xqeB-2a6yA:
undetectable		 4xqeB-2a6yA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2a6y EMP47P (FORM1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 131
PHE A 148
LEU A 127
MET A 153
ILE A  87
 None
 1.16A 5ienA-2a6yA:
undetectable		 5ienA-2a6yA:
17.72