SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XF3_A_J01A500_1 (ORF12)	2a70	EMP47P (Saccharomyces cerevisiae)	5 / 10	VAL A 180 ILE A 164 LEU A 115 GLY A 129 ALA A 149	None None None None EDO A 4 ( 4.9A)	0.96A	2xf3A-2a70A: undetectable	2xf3A-2a70A: 17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ARU_A_PNXA607_1 (CHITINASE A)	2a70	EMP47P (Saccharomyces cerevisiae)	5 / 8	VAL A 27 GLY A 34 THR A 33 GLU A 35 ALA A 37	None	1.31A	3aruA-2a70A: undetectable	3aruA-2a70A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SOA_A_DB8A445_1 (CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER)	2a70	EMP47P (Saccharomyces cerevisiae)	4 / 6	LEU A 127 VAL A 117 PHE A 74 VAL A 180	None	1.00A	3soaA-2a70A: undetectable	3soaA-2a70A: 19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RFQ_A_SAMA401_1 (HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG)	2a70	EMP47P (Saccharomyces cerevisiae)	4 / 4	THR A 47 GLY A 207 ASP A 84 SER A 52	None	1.32A	4rfqA-2a70A: undetectable	4rfqA-2a70A: 23.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XF3_A_J01A500_1","ORF12","2a70","EMP47P","Saccharomyces cerevisiae",5,"VAL A 180;ILE A 164;LEU A 115;GLY A 129;ALA A 149","None;None;None;None;EDO A   4 ( 4.9A)","0.96A","2xf3A-2a70A:undetectable","2xf3A-2a70A:17.47"],["3ARU_A_PNXA607_1","CHITINASE A","2a70","EMP47P","Saccharomyces cerevisiae",5,"VAL A  27;GLY A  34;THR A  33;GLU A  35;ALA A  37","None","1.31A","3aruA-2a70A:undetectable","3aruA-2a70A:18.18"],["3SOA_A_DB8A445_1","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER","2a70","EMP47P","Saccharomyces cerevisiae",4,"LEU A 127;VAL A 117;PHE A  74;VAL A 180","None","1.00A","3soaA-2a70A:undetectable","3soaA-2a70A:19.26"],["4RFQ_A_SAMA401_1","HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG","2a70","EMP47P","Saccharomyces cerevisiae",4,"THR A  47;GLY A 207;ASP A  84;SER A  52","None","1.32A","4rfqA-2a70A:undetectable","4rfqA-2a70A:23.83"]]