SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CAS_A_ASDA332_1 (3-OXO-5-BETA-STEROID 4-DEHYDROGENASE)	2a79	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 (Rattus norvegicus)	5 / 10	TYR B 116 ASN B 38 VAL B 36 VAL B 35 LEU B 51	None	1.47A	3casA-2a79B: undetectable	3casA-2a79B: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_B_SAMB301_0 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	2a79	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 (Rattus norvegicus)	5 / 12	GLY B 391 ALA B 368 ILE B 396 LEU B 393 ALA B 349	None	0.99A	5bw4B-2a79B: undetectable	5bw4B-2a79B: 18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2a79	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 (Rattus norvegicus)	3 / 3	PHE B 78 ILE B 37 ASP B 86	None	0.69A	5cswA-2a79B: undetectable	5cswA-2a79B: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CSW_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	2a79	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 (Rattus norvegicus)	3 / 3	PHE B 78 ILE B 37 ASP B 86	None	0.75A	5cswB-2a79B: undetectable	5cswB-2a79B: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_N_PCFN606_0 (CYTOCHROME B)	2a79	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 (Rattus norvegicus)	5 / 12	PHE B 126 MET B 125 MET B 123 ALA B 122 PHE B 54	None	1.44A	6hu9N-2a79B: undetectable	6hu9N-2a79B: 21.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3CAS_A_ASDA332_1","3-OXO-5-BETA-STEROID 4-DEHYDROGENASE","2a79","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2","Rattus norvegicus",5,"TYR B 116;ASN B  38;VAL B  36;VAL B  35;LEU B  51","None","1.47A","3casA-2a79B:undetectable","3casA-2a79B:20.94"],["5BW4_B_SAMB301_0","16S RRNA (ADENINE(1408)-N(1))-METHYLTRANSFERASE","2a79","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2","Rattus norvegicus",5,"GLY B 391;ALA B 368;ILE B 396;LEU B 393;ALA B 349","None","0.99A","5bw4B-2a79B:undetectable","5bw4B-2a79B:18.74"],["5CSW_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2a79","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2","Rattus norvegicus",3,"PHE B  78;ILE B  37;ASP B  86","None","0.69A","5cswA-2a79B:undetectable","5cswA-2a79B:18.06"],["5CSW_B_P06B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","2a79","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2","Rattus norvegicus",3,"PHE B  78;ILE B  37;ASP B  86","None","0.75A","5cswB-2a79B:undetectable","5cswB-2a79B:18.06"],["6HU9_N_PCFN606_0","CYTOCHROME B","2a79","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2","Rattus norvegicus",5,"PHE B 126;MET B 125;MET B 123;ALA B 122;PHE B  54","None","1.44A","6hu9N-2a79B:undetectable","6hu9N-2a79B:21.37"]]