SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.31A 1dfoB-2a7lA:
undetectable		 1dfoB-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.31A 1dfoA-2a7lA:
undetectable		 1dfoA-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.31A 1dfoD-2a7lA:
undetectable		 1dfoD-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.31A 1dfoC-2a7lA:
undetectable		 1dfoC-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 GLU A  52
TYR A  49
PHE A  54
 None
 0.86A 1eqbB-2a7lA:
undetectable		 1eqbB-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 GLU A  52
TYR A  49
PHE A  54
 None
 0.86A 1eqbA-2a7lA:
undetectable		 1eqbA-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 GLU A  52
TYR A  49
PHE A  54
 None
 0.85A 1eqbD-2a7lA:
undetectable		 1eqbD-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 GLU A  52
TYR A  49
PHE A  54
 None
 0.86A 1eqbC-2a7lA:
undetectable		 1eqbC-2a7lA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 6 GLU A  52
TYR A  49
PHE A  54
PRO A  79
 None
 1.39A 2vmyA-2a7lA:
undetectable		 2vmyA-2a7lA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 PRO A  79
GLU A  50
TYR A  49
 None
 0.75A 2zmbA-2a7lA:
undetectable		 2zmbA-2a7lA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		5 / 12 PHE A  73
LEU A  95
GLN A  70
VAL A 108
VAL A  84
 None
 1.11A 4wnwB-2a7lA:
undetectable		 4wnwB-2a7lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		3 / 3 ILE A  90
VAL A  71
PRO A  69
 None
 0.73A 5uunA-2a7lA:
undetectable		 5uunA-2a7lA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens) 		4 / 7 LEU A 103
HIS A  89
ASP A  98
THR A  96
 None
 1.26A 5z85C-2a7lA:
undetectable
5z85N-2a7lA:
undetectable
5z85P-2a7lA:
undetectable		 5z85C-2a7lA:
22.64
5z85N-2a7lA:
11.46
5z85P-2a7lA:
22.64