SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 5 ASP A 191
HIS A 235
HIS A 104
HIS A 109
 ZN  A 251 ( 2.4A)
ZN  A 251 (-3.3A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.2A)
 1.23A 1ei6A-2a7mA:
undetectable		 1ei6A-2a7mA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 169
HIS A 104
ASP A 108
VAL A  35
PRO A  34
 ZN  A 252 (-3.3A)
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.7A)
None
None
 1.31A 1ituB-2a7mA:
undetectable		 1ituB-2a7mA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 ARG A 219
GLY A 153
ASP A 154
 None
 0.55A 1kf6A-2a7mA:
undetectable
1kf6B-2a7mA:
undetectable		 1kf6A-2a7mA:
18.21
1kf6B-2a7mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 10 GLY A 172
HIS A 173
VAL A 123
ALA A 130
ALA A 131
 None
 1.03A 1likA-2a7mA:
undetectable		 1likA-2a7mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 5 ILE A  83
ILE A 190
ILE A   9
LEU A 105
 GOL  A 825 (-4.8A)
None
None
None
 0.94A 1zgyA-2a7mA:
undetectable		 1zgyA-2a7mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 11 GLY A 207
SER A  23
PHE A 205
ASN A 198
ASP A 108
 None
None
None
None
ZN  A 251 ( 2.7A)
 0.75A 2c2bE-2a7mA:
0.0
2c2bF-2a7mA:
0.0		 2c2bE-2a7mA:
19.92
2c2bF-2a7mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 104
HIS A 109
GLY A 234
HIS A 173
ASP A  50
 ZN  A 252 (-3.3A)
ZN  A 251 (-3.2A)
None
None
None
 1.08A 2pgrA-2a7mA:
undetectable		 2pgrA-2a7mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 ASP A 108
ASP A 191
HIS A 235
LEU A  16
 ZN  A 251 ( 2.7A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.3A)
GOL  A 805 (-4.9A)
 0.87A 2q0iA-2a7mA:
13.7		 2q0iA-2a7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 11 ASP A 108
HIS A 109
HIS A 169
ASP A 191
HIS A 235
 ZN  A 251 ( 2.7A)
ZN  A 251 (-3.2A)
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.3A)
 0.67A 2q0jB-2a7mA:
13.7		 2q0jB-2a7mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 11 HIS A 109
HIS A 169
ASP A 191
HIS A 235
LEU A  16
 ZN  A 251 (-3.2A)
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.3A)
GOL  A 805 (-4.9A)
 0.96A 2q0jB-2a7mA:
13.7		 2q0jB-2a7mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 SER A 242
HIS A 235
ASP A  50
 None
ZN  A 251 (-3.3A)
None
 0.71A 2wa2B-2a7mA:
undetectable		 2wa2B-2a7mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 169
HIS A 104
HIS A 173
 ZN  A 252 (-3.3A)
ZN  A 252 (-3.3A)
None
 0.74A 3ag2A-2a7mA:
undetectable		 3ag2A-2a7mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 169
HIS A 104
HIS A 173
 ZN  A 252 (-3.3A)
ZN  A 252 (-3.3A)
None
 0.73A 3ag4A-2a7mA:
undetectable		 3ag4A-2a7mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 PHE A 177
GLY A 160
VAL A   3
LEU A  40
 None
 0.88A 3bgdB-2a7mA:
undetectable		 3bgdB-2a7mA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 VAL A 123
LEU A 143
GLY A 111
ALA A 110
LEU A 105
 None
 1.03A 3n8wA-2a7mA:
undetectable		 3n8wA-2a7mA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 VAL A 123
LEU A 143
GLY A 111
ALA A 110
LEU A 105
 None
 1.03A 3n8zA-2a7mA:
undetectable		 3n8zA-2a7mA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 VAL A 123
LEU A 143
GLY A 111
ALA A 110
LEU A 105
 None
 1.00A 3pghC-2a7mA:
undetectable		 3pghC-2a7mA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 7 ASP A  50
SER A 103
HIS A 169
HIS A 173
 None
None
ZN  A 252 (-3.3A)
None
 1.37A 4arcA-2a7mA:
undetectable		 4arcA-2a7mA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 10 HIS A 104
HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.63A 4c1dB-2a7mA:
16.0		 4c1dB-2a7mA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 11 HIS A 104
HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.64A 4c1fA-2a7mA:
16.7
4c1fB-2a7mA:
16.7		 4c1fA-2a7mA:
24.64
4c1fB-2a7mA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 9 HIS A 104
HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.61A 4c1hA-2a7mA:
15.8		 4c1hA-2a7mA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.63A 4exsB-2a7mA:
14.8		 4exsB-2a7mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 11 ALA A 131
GLY A 111
ASN A 113
HIS A 106
GLU A 136
 None
None
None
ZN  A 252 ( 3.2A)
None
 1.48A 4j83A-2a7mA:
0.0		 4j83A-2a7mA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 4 VAL A  58
THR A  78
GLU A  79
GLU A  80
 None
GOL  A 810 (-4.6A)
None
None
 1.03A 4l78A-2a7mA:
0.0		 4l78A-2a7mA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.71A 5a5zA-2a7mA:
3.6		 5a5zA-2a7mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		6 / 11 HIS A 104
HIS A 106
ASP A 108
HIS A 109
HIS A 169
HIS A 235
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 251 (-3.2A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.52A 5ayaA-2a7mA:
15.0		 5ayaA-2a7mA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 235
ASP A 191
LEU A 176
ILE A 190
HIS A 104
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
None
None
ZN  A 252 (-3.3A)
 1.15A 5dv4A-2a7mA:
undetectable		 5dv4A-2a7mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 104
HIS A 106
PHE A 107
ASP A 191
LEU A  16
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
GOL  A 805 ( 4.4A)
ZN  A 251 ( 2.4A)
GOL  A 805 (-4.9A)
 1.20A 5eeiA-2a7mA:
undetectable		 5eeiA-2a7mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 104
HIS A 106
PHE A 107
ASP A 191
LEU A  16
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
GOL  A 805 ( 4.4A)
ZN  A 251 ( 2.4A)
GOL  A 805 (-4.9A)
 1.21A 5eeiB-2a7mA:
undetectable		 5eeiB-2a7mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 104
HIS A 106
PHE A 107
ASP A 191
LEU A  16
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
GOL  A 805 ( 4.4A)
ZN  A 251 ( 2.4A)
GOL  A 805 (-4.9A)
 1.20A 5eenB-2a7mA:
undetectable		 5eenB-2a7mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A 104
HIS A 106
PHE A 107
ASP A 191
LEU A  16
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
GOL  A 805 ( 4.4A)
ZN  A 251 ( 2.4A)
GOL  A 805 (-4.9A)
 1.16A 5ef8B-2a7mA:
undetectable		 5ef8B-2a7mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 8 GLU A 127
HIS A 173
GLY A 168
HIS A 104
ASP A 191
 None
None
None
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
 1.07A 5f8yA-2a7mA:
undetectable		 5f8yA-2a7mA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 8 GLU A 127
HIS A 173
GLY A 168
HIS A 104
ASP A 191
 None
None
None
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
 1.06A 5f8yB-2a7mA:
undetectable		 5f8yB-2a7mA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 111
ASP A 191
HIS A 104
ALA A 131
ILE A  73
 None
ZN  A 251 ( 2.4A)
ZN  A 252 (-3.3A)
None
None
 1.26A 5igvA-2a7mA:
undetectable		 5igvA-2a7mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 PRO A  94
LEU A  87
PHE A 116
GLY A 114
GLY A 112
 GOL  A 820 ( 4.3A)
None
None
GOL  A 825 ( 3.8A)
GOL  A 825 (-3.6A)
 1.16A 5l6eA-2a7mA:
undetectable		 5l6eA-2a7mA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 ASP A 191
HIS A 169
HIS A 104
HIS A 235
 ZN  A 251 ( 2.4A)
ZN  A 252 (-3.3A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.90A 5nekD-2a7mA:
undetectable		 5nekD-2a7mA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 10 HIS A 104
HIS A 106
HIS A 109
HIS A 169
ASP A 191
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 (-3.2A)
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
 0.42A 5nzwA-2a7mA:
5.8		 5nzwA-2a7mA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 235
ASP A 191
HIS A 109
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.2A)
 0.72A 5oexA-2a7mA:
undetectable		 5oexA-2a7mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 235
ASP A 191
HIS A 109
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.2A)
 0.75A 5oexB-2a7mA:
undetectable		 5oexB-2a7mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 235
ASP A 191
HIS A 109
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.2A)
 0.72A 5oexC-2a7mA:
undetectable		 5oexC-2a7mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		3 / 3 HIS A 235
ASP A 191
HIS A 109
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.2A)
 0.74A 5oexD-2a7mA:
0.0		 5oexD-2a7mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		4 / 8 HIS A 106
ASP A 108
HIS A 169
HIS A 235
 ZN  A 252 ( 3.2A)
ZN  A 251 ( 2.7A)
ZN  A 252 (-3.3A)
ZN  A 251 (-3.3A)
 0.69A 5zj8A-2a7mA:
15.3		 5zj8A-2a7mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0F-2a7mA:
undetectable		 6ew0F-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0G-2a7mA:
undetectable		 6ew0G-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 GLY A 168
GLY A 207
SER A 216
ASP A 191
GLN A 124
 None
None
None
ZN  A 251 ( 2.4A)
None
 1.08A 6exiC-2a7mA:
undetectable
6exiD-2a7mA:
undetectable		 6exiC-2a7mA:
16.24
6exiD-2a7mA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE
(Bacillus
thuringiensis) 		5 / 12 GLN A 124
GLY A 168
GLY A 207
SER A 216
ASP A 191
 None
None
None
None
ZN  A 251 ( 2.4A)
 1.06A 6exiC-2a7mA:
undetectable
6exiD-2a7mA:
undetectable		 6exiC-2a7mA:
16.24
6exiD-2a7mA:
16.24