SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 6 VAL A 322
GLY A 321
ALA A  93
LEU A  94
 None
 0.76A 1e7bB-2a7nA:
undetectable		 1e7bB-2a7nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 6 CYH A 242
ASP A 238
VAL A 250
GLY A 232
 None
 1.28A 1ekjC-2a7nA:
undetectable
1ekjD-2a7nA:
undetectable		 1ekjC-2a7nA:
20.27
1ekjD-2a7nA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 LEU A 130
ALA A 145
ILE A 115
GLY A 140
 None
 0.81A 1sv9A-2a7nA:
undetectable		 1sv9A-2a7nA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 11 THR A 109
TYR A 131
GLU A 136
LEU A 203
ILE A 133
 None
FMN  A 390 (-4.2A)
None
None
None
 1.05A 1t6zB-2a7nA:
undetectable		 1t6zB-2a7nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 TYR A 150
ALA A 101
ILE A 103
ALA A  93
LEU A 118
 None
 1.26A 1udtA-2a7nA:
undetectable		 1udtA-2a7nA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 10 PHE A 212
LEU A 220
TRP A 219
ARG A 135
THR A 157
 None
 1.50A 2b8jB-2a7nA:
0.0		 2b8jB-2a7nA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 LEU A 326
LEU A 306
ASP A 123
CYH A 122
ALA A  95
 None
 1.12A 2bm9A-2a7nA:
undetectable		 2bm9A-2a7nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 11 LEU A  86
VAL A 322
GLY A 321
ALA A  93
LEU A  94
 None
 1.13A 2bxgA-2a7nA:
undetectable		 2bxgA-2a7nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 LEU A 252
VAL A 304
ILE A 293
VAL A 281
ILE A 283
 None
 0.97A 2pynB-2a7nA:
undetectable		 2pynB-2a7nA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 11 PHE A 287
ASP A 292
PHE A  49
GLN A 354
PRO A 350
 None
 1.36A 2vcdA-2a7nA:
undetectable		 2vcdA-2a7nA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 THR A 277
GLN A 272
SER A 273
CYH A 242
 None
 1.34A 2xz5A-2a7nA:
undetectable
2xz5C-2a7nA:
undetectable		 2xz5A-2a7nA:
19.74
2xz5C-2a7nA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 11 ILE A 345
LEU A 337
VAL A 304
PRO A  74
LEU A  75
 None
 1.08A 3a51A-2a7nA:
undetectable		 3a51A-2a7nA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 ILE A 345
LEU A 337
VAL A 304
PRO A  74
LEU A  75
 None
 1.09A 3a51D-2a7nA:
undetectable		 3a51D-2a7nA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 GLY A 246
ALA A 247
ASP A 248
THR A 157
 None
 0.55A 3el0A-2a7nA:
undetectable		 3el0A-2a7nA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 TYR A 131
TYR A  26
GLY A 256
SER A 285
ASN A  83
 FMN  A 390 (-4.2A)
FMN  A 390 (-4.2A)
FMN  A 390 (-3.2A)
FMN  A 390 (-3.9A)
None
 1.28A 3hiiA-2a7nA:
0.0		 3hiiA-2a7nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		3 / 3 ALA A 160
VAL A 159
GLN A 259
 None
 0.74A 3of4B-2a7nA:
undetectable		 3of4B-2a7nA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 11 LEU A 314
THR A 310
VAL A 322
SER A 111
LEU A  92
 None
 1.28A 3tbgA-2a7nA:
undetectable		 3tbgA-2a7nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		3 / 3 PRO A  79
THR A  80
LEU A  94
 FMN  A 390 (-3.8A)
FMN  A 390 (-4.5A)
None
 0.76A 3ttrA-2a7nA:
undetectable		 3ttrA-2a7nA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 10 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.43A 3u9fI-2a7nA:
undetectable		 3u9fI-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 9 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.42A 3u9fP-2a7nA:
undetectable		 3u9fP-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 10 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.40A 3u9fR-2a7nA:
undetectable		 3u9fR-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 PHE A  44
SER A 265
LEU A 252
VAL A 281
VAL A 269
 None
 1.38A 3u9fP-2a7nA:
undetectable
3u9fS-2a7nA:
undetectable		 3u9fP-2a7nA:
19.52
3u9fS-2a7nA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 GLN A 259
HIS A 255
VAL A 159
VAL A 161
 None
FMN  A 390 (-3.6A)
None
None
 1.15A 3uy4A-2a7nA:
undetectable		 3uy4A-2a7nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 5 ILE A 133
ALA A 110
MET A 208
PHE A 184
 None
FMN  A 390 ( 4.5A)
None
None
 1.09A 4dc3B-2a7nA:
2.2		 4dc3B-2a7nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 5 SER A 291
GLY A 290
VAL A   8
ASP A 332
 None
 1.11A 4eohA-2a7nA:
undetectable		 4eohA-2a7nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 GLY A 246
ALA A 247
ASP A 248
THR A 157
 None
 0.87A 4eyrB-2a7nA:
undetectable		 4eyrB-2a7nA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 7 ALA A  95
LEU A 126
TYR A 150
LEU A 118
 None
 1.04A 4iomA-2a7nA:
2.1		 4iomA-2a7nA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 5 LEU A 306
LEU A 311
LEU A 329
ASN A  83
 None
 1.28A 4n09B-2a7nA:
2.3		 4n09B-2a7nA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 ALA A 110
ASN A 112
ALA A  85
GLY A  84
LEU A  86
 FMN  A 390 ( 4.5A)
None
None
None
None
 1.00A 4oaeA-2a7nA:
undetectable		 4oaeA-2a7nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 THR A 148
LEU A 107
VAL A 154
LEU A 153
 None
 0.86A 4r38B-2a7nA:
undetectable		 4r38B-2a7nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 8 THR A 148
LEU A 107
VAL A 154
LEU A 153
 None
 0.83A 4r38D-2a7nA:
undetectable		 4r38D-2a7nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		5 / 12 LEU A 282
ALA A  64
ILE A 345
THR A 152
PRO A 104
 None
 1.41A 5ewjC-2a7nA:
undetectable
5ewjD-2a7nA:
undetectable		 5ewjC-2a7nA:
22.25
5ewjD-2a7nA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 5 TYR A  11
TYR A 312
GLY A 313
GLY A 321
 None
 1.00A 5x7pA-2a7nA:
undetectable		 5x7pA-2a7nA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2a7n L(+)-MANDELATE
DEHYDROGENASE
(Pseudomonas
putida;
Spinacia
oleracea) 		4 / 7 ASP A 168
GLY A 257
GLY A  30
VAL A  37
 None
 0.92A 6ekzA-2a7nA:
undetectable		 6ekzA-2a7nA:
10.91