SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 8 CYH A 446
LEU A 531
ALA A 527
LEU A 530
 None
 0.98A 1hwiC-2a7sA:
undetectable		 1hwiC-2a7sA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 350
LEU A 528
ILE A 524
ILE A 318
LEU A 321
 None
 1.11A 1kyvA-2a7sA:
undetectable
1kyvE-2a7sA:
undetectable		 1kyvA-2a7sA:
14.37
1kyvE-2a7sA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 318
LEU A 321
GLY A 350
LEU A 528
ILE A 524
 None
 1.14A 1kyvB-2a7sA:
undetectable
1kyvC-2a7sA:
undetectable		 1kyvB-2a7sA:
14.37
1kyvC-2a7sA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 318
LEU A 321
GLY A 350
LEU A 528
ILE A 524
 None
 1.11A 1kyvC-2a7sA:
undetectable
1kyvD-2a7sA:
undetectable		 1kyvC-2a7sA:
14.37
1kyvD-2a7sA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 318
LEU A 321
GLY A 350
LEU A 528
ILE A 524
 None
 1.12A 1kyvD-2a7sA:
undetectable
1kyvE-2a7sA:
undetectable		 1kyvD-2a7sA:
14.37
1kyvE-2a7sA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 279
GLY A 342
ASP A 324
ILE A 524
ALA A 282
 None
 0.94A 1sguB-2a7sA:
undetectable		 1sguB-2a7sA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 181
ILE A 140
ALA A 177
LEU A 146
ILE A 132
 None
 1.06A 1xzxX-2a7sA:
undetectable		 1xzxX-2a7sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 170
TYR A 128
ASN A 174
LEU A 201
ASP A 203
 None
 1.40A 2iyfB-2a7sA:
undetectable		 2iyfB-2a7sA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 6 ASP A  96
VAL A 127
PHE A 120
PRO A  93
 None
 1.34A 2q6oB-2a7sA:
undetectable		 2q6oB-2a7sA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 213
VAL A 196
GLY A 152
GLY A 154
 None
 0.79A 2vinA-2a7sA:
undetectable		 2vinA-2a7sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 252
SER A 185
ALA A 200
PRO A 199
THR A 247
 None
 1.18A 2zifB-2a7sA:
undetectable		 2zifB-2a7sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 113
LEU A  40
GLY A  97
PRO A  42
ILE A 132
 None
 1.35A 2zznB-2a7sA:
undetectable		 2zznB-2a7sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 181
ILE A 140
ALA A 177
LEU A 146
ILE A 132
 None
 1.04A 3gwsX-2a7sA:
undetectable		 3gwsX-2a7sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 152
GLY A 154
LEU A 124
ALA A 191
ASN A 150
 None
 1.10A 3kkzA-2a7sA:
undetectable		 3kkzA-2a7sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 525
GLY A 522
THR A 520
LEU A 450
 None
 0.94A 3si7C-2a7sA:
undetectable
3si7D-2a7sA:
undetectable		 3si7C-2a7sA:
20.48
3si7D-2a7sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 344
LEU A 450
LEU A 528
ILE A 424
LEU A 388
 None
 0.88A 3vrmA-2a7sA:
undetectable		 3vrmA-2a7sA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  96
GLU A 126
GLY A 125
 None
 0.64A 3w9tA-2a7sA:
undetectable		 3w9tA-2a7sA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  67
ILE A 149
ALA A  65
PHE A 259
 None
 1.07A 4dc3B-2a7sA:
undetectable		 4dc3B-2a7sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 195
ALA A 153
GLN A 115
TYR A 128
 None
 1.33A 4gboA-2a7sA:
undetectable		 4gboA-2a7sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 503
ILE A 427
VAL A 514
ALA A 451
 None
 0.82A 5cu6A-2a7sA:
undetectable		 5cu6A-2a7sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  70
LEU A  40
ARG A  60
 None
 0.96A 5e8qA-2a7sA:
undetectable		 5e8qA-2a7sA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 503
ILE A 427
VAL A 514
ALA A 451
 None
 0.78A 5ospA-2a7sA:
undetectable		 5ospA-2a7sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 195
ALA A 153
GLN A 115
TYR A 128
 None
 1.34A 5uizA-2a7sA:
undetectable		 5uizA-2a7sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		5 / 10 PRO A 516
PRO A 453
GLY A 525
THR A 526
ILE A 524
 None
 1.10A 5vyhA-2a7sA:
undetectable		 5vyhA-2a7sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 331
GLN A 335
GLN A 355
ASP A 313
 None
 1.30A 5y9aA-2a7sA:
2.3		 5y9aA-2a7sA:
17.03