SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 ALA A  45
VAL A  64
TRP A  68
 None
 0.81A 1av2A-2a7wA:
undetectable
1av2B-2a7wA:
undetectable		 1av2A-2a7wA:
8.04
1av2B-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  68
ALA A  45
VAL A  64
 None
 0.68A 1av2C-2a7wA:
undetectable
1av2D-2a7wA:
undetectable		 1av2C-2a7wA:
8.04
1av2D-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 5 HIS A  70
GLU A  43
ALA A  45
HIS A  59
 None
 1.42A 1errA-2a7wA:
undetectable
1errB-2a7wA:
undetectable		 1errA-2a7wA:
19.20
1errB-2a7wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 4 THR A  48
LEU A  67
VAL A  41
LEU A  74
 None
 1.02A 1fbmB-2a7wA:
undetectable		 1fbmB-2a7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 ALA A  45
VAL A  64
TRP A  68
 None
 0.81A 1w5uA-2a7wA:
undetectable
1w5uB-2a7wA:
undetectable		 1w5uA-2a7wA:
8.04
1w5uB-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  68
ALA A  45
VAL A  64
 None
 0.75A 1w5uA-2a7wA:
undetectable
1w5uB-2a7wA:
undetectable		 1w5uA-2a7wA:
8.04
1w5uB-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 ALA A  45
VAL A  64
TRP A  68
 None
 0.75A 2izqA-2a7wA:
undetectable
2izqB-2a7wA:
undetectable		 2izqA-2a7wA:
8.04
2izqB-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  68
ALA A  45
VAL A  64
 None
 0.87A 2izqC-2a7wA:
undetectable
2izqD-2a7wA:
undetectable		 2izqC-2a7wA:
8.04
2izqD-2a7wA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  68
ALA A  45
VAL A  64
 None
 0.84A 3l8lA-2a7wA:
undetectable
3l8lB-2a7wA:
undetectable		 3l8lA-2a7wA:
8.04
3l8lB-2a7wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  68
ALA A  45
VAL A  64
 None
 0.85A 3l8lC-2a7wA:
undetectable
3l8lD-2a7wA:
undetectable		 3l8lC-2a7wA:
8.04
3l8lD-2a7wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 5 LEU A   6
LYS A   7
ALA A  10
LEU A  13
 None
 0.83A 5vkqA-2a7wA:
3.5
5vkqD-2a7wA:
3.5		 5vkqA-2a7wA:
5.25
5vkqD-2a7wA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 5 LEU A   6
LYS A   7
ALA A  10
LEU A  13
 None
 0.83A 5vkqA-2a7wA:
3.5
5vkqB-2a7wA:
3.5		 5vkqA-2a7wA:
5.25
5vkqB-2a7wA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 5 LEU A   6
LYS A   7
ALA A  10
LEU A  13
 None
 0.82A 5vkqB-2a7wA:
3.5
5vkqC-2a7wA:
3.5		 5vkqB-2a7wA:
5.25
5vkqC-2a7wA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE
(Chromobacterium
violaceum) 		4 / 5 LEU A   6
LYS A   7
ALA A  10
LEU A  13
 None
 0.83A 5vkqC-2a7wA:
3.5
5vkqD-2a7wA:
3.5		 5vkqC-2a7wA:
5.25
5vkqD-2a7wA:
5.25