SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 8 PHE A 110
GLU A 131
ILE A 157
LEU A 164
 None
BCN  A 501 (-3.5A)
None
None
 0.92A 1hmyA-2a81A:
undetectable		 1hmyA-2a81A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 ASN A 211
ALA A  99
VAL A  90
ALA A  89
LEU A 218
 None
 1.23A 1udtA-2a81A:
undetectable		 1udtA-2a81A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 7 PHE A 127
LEU A 184
ALA A  99
ALA A 105
 None
 1.02A 2vcvG-2a81A:
undetectable		 2vcvG-2a81A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.18A 2zj0A-2a81A:
undetectable		 2zj0A-2a81A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.12A 3ce6A-2a81A:
undetectable		 3ce6A-2a81A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.12A 3ce6C-2a81A:
undetectable		 3ce6C-2a81A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 PHE A 112
ALA A 105
PHE A  24
LEU A  86
GLY A  53
 None
 1.15A 4kykA-2a81A:
undetectable
4kykB-2a81A:
undetectable		 4kykA-2a81A:
21.54
4kykB-2a81A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.13A 4lvcA-2a81A:
undetectable		 4lvcA-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.12A 4lvcC-2a81A:
undetectable		 4lvcC-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 HIS A 149
THR A 153
LEU A 114
LEU A 145
GLY A 146
 None
 1.43A 4pfjB-2a81A:
undetectable		 4pfjB-2a81A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 8 THR A 148
ILE A 215
VAL A  83
MET A 115
 None
None
BCN  A 501 (-4.6A)
None
 1.02A 4r38B-2a81A:
undetectable		 4r38B-2a81A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 11 ALA A 142
VAL A  83
TYR A  87
GLY A 137
SER A 225
 None
BCN  A 501 (-4.6A)
None
None
None
 1.07A 4xp4A-2a81A:
undetectable		 4xp4A-2a81A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 ASP A 117
PHE A  58
LEU A  15
THR A  14
ARG A  11
 None
 1.38A 5hnxB-2a81A:
undetectable		 5hnxB-2a81A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 4 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.12A 5m5kA-2a81A:
undetectable		 5m5kA-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 4 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.14A 5m5kC-2a81A:
undetectable		 5m5kC-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 4 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.10A 5m66B-2a81A:
undetectable		 5m66B-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2a81 CARB
(Pectobacterium
carotovorum) 		3 / 3 HIS A  17
ASN A  22
ALA A  60
 None
None
ACO  A 500 (-3.7A)
 0.65A 5n4tB-2a81A:
undetectable		 5n4tB-2a81A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 8 ARG A 173
TYR A 172
ILE A 157
LEU A 114
TYR A  87
 None
 1.41A 5nooD-2a81A:
undetectable		 5nooD-2a81A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.17A 5vlmE-2a81A:
undetectable		 5vlmE-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2a81 CARB
(Pectobacterium
carotovorum) 		5 / 12 MET A 195
ALA A  47
ILE A 204
ARG A 208
VAL A  93
 None
 1.26A 5vlmG-2a81A:
0.4		 5vlmG-2a81A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 4 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.07A 6f3mB-2a81A:
undetectable		 6f3mB-2a81A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.08A 6f3mD-2a81A:
undetectable		 6f3mD-2a81A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.13A 6gbnA-2a81A:
undetectable		 6gbnA-2a81A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2a81 CARB
(Pectobacterium
carotovorum) 		4 / 5 GLN A 220
THR A 221
THR A 148
LEU A  91
 None
 1.13A 6gbnD-2a81A:
undetectable		 6gbnD-2a81A:
22.37