SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 6 ILE A 452
ASN A 450
SER A 430
ASN A 427
 None
 1.27A 1h7xA-2a8bA:
undetectable		 1h7xA-2a8bA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 6 ILE A 452
ASN A 450
SER A 430
ASN A 427
 None
 1.27A 1h7xC-2a8bA:
undetectable		 1h7xC-2a8bA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 6 ILE A 452
ASN A 450
SER A 430
ASN A 427
 None
 1.27A 1h7xD-2a8bA:
undetectable		 1h7xD-2a8bA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		5 / 12 ARG A 509
GLY A 513
VAL A 515
GLU A 516
ASP A 474
 None
 1.48A 1jdvE-2a8bA:
undetectable
1jdvF-2a8bA:
undetectable		 1jdvE-2a8bA:
22.62
1jdvF-2a8bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		5 / 12 LEU A 434
ILE A 463
THR A 465
ASP A 475
LEU A 535
 None
 1.14A 2jn3A-2a8bA:
undetectable		 2jn3A-2a8bA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		3 / 3 ASN A 419
ASN A 448
ARG A 627
 None
 0.78A 2rlcA-2a8bA:
undetectable		 2rlcA-2a8bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 4 VAL A 502
ASP A 474
LEU A 434
ARG A 420
 None
 1.27A 2ziaA-2a8bA:
undetectable		 2ziaA-2a8bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 5 PRO A 428
VAL A 405
THR A 595
GLY A 591
 None
 1.03A 3elzB-2a8bA:
undetectable		 3elzB-2a8bA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		6 / 12 GLY A 591
VAL A 586
GLY A 629
MET A 630
LEU A 623
ILE A 452
 None
 1.31A 3ku1A-2a8bA:
undetectable		 3ku1A-2a8bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		6 / 12 GLY A 591
VAL A 586
GLY A 629
MET A 630
LEU A 623
ILE A 452
 None
 1.29A 3ku1C-2a8bA:
undetectable		 3ku1C-2a8bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens) 		4 / 7 MET A 479
ARG A 627
VAL A 586
MET A 490
 None
 1.47A 4klaA-2a8bA:
0.6		 4klaA-2a8bA:
22.87