SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 ALA A 249
VAL A 288
TRP A 274
 None
 0.96A 1c4dC-2a8iA:
undetectable
1c4dD-2a8iA:
undetectable		 1c4dC-2a8iA:
5.37
1c4dD-2a8iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.26A 1errB-2a8iA:
undetectable		 1errB-2a8iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 GLY A 272
VAL A 298
ALA A 248
HIS A  47
LEU A  45
 None
 1.38A 1kiaD-2a8iA:
undetectable		 1kiaD-2a8iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 9 LEU A 302
VAL A 343
GLY A 342
VAL A 406
ILE A 408
 None
 1.36A 2a1oB-2a8iA:
undetectable		 2a1oB-2a8iA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 GLY A 294
LEU A 255
GLY A 230
ASN A 100
ALA A  48
 None
 1.03A 2bm9F-2a8iA:
undetectable		 2bm9F-2a8iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 7 SER A 394
LEU A 396
THR A 374
GLY A  49
 None
 0.87A 2ddwB-2a8iA:
undetectable		 2ddwB-2a8iA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 5 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.29A 2jfaA-2a8iA:
undetectable		 2jfaA-2a8iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 5 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.25A 2qxsA-2a8iA:
undetectable		 2qxsA-2a8iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 5 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.26A 2qxsB-2a8iA:
undetectable		 2qxsB-2a8iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 THR A 290
GLY A 342
GLY A 341
THR A 373
LEU A 319
 None
 1.05A 2uvnA-2a8iA:
undetectable		 2uvnA-2a8iA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 8 LEU A 232
ALA A  50
GLY A 294
LEU A 297
GLY A 272
 None
 1.46A 2yfxA-2a8iA:
undetectable		 2yfxA-2a8iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 SER A 252
GLY A 264
GLY A 294
 None
 0.51A 3bogA-2a8iA:
undetectable
3bogC-2a8iA:
undetectable		 3bogA-2a8iA:
undetectable
3bogC-2a8iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 GLN A 265
GLY A 264
GLY A 270
GLY A 272
LEU A 302
 None
 1.08A 3kkzB-2a8iA:
undetectable		 3kkzB-2a8iA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 ALA A 194
ARG A 198
LYS A 202
 None
 0.82A 3kp3B-2a8iA:
undetectable		 3kp3B-2a8iA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 ALA A 194
ARG A 198
LYS A 202
 None
 0.83A 3kp5B-2a8iA:
undetectable		 3kp5B-2a8iA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 THR A 286
VAL A 288
GLU A 276
 None
 0.71A 3v4tA-2a8iA:
undetectable
3v4tD-2a8iA:
undetectable		 3v4tA-2a8iA:
24.54
3v4tD-2a8iA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 ALA A  72
GLY A  42
LEU A 364
LEU A 415
ALA A  85
 None
 1.03A 4lg1A-2a8iA:
undetectable		 4lg1A-2a8iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 ALA A  72
GLY A  42
LEU A 364
LEU A 415
ALA A  85
 None
 1.02A 4lg1B-2a8iA:
undetectable		 4lg1B-2a8iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 12 ALA A  72
GLY A  42
LEU A 364
LEU A 415
ALA A  85
 None
 1.03A 4lg1C-2a8iA:
undetectable		 4lg1C-2a8iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 0.98A 5x7pA-2a8iA:
undetectable		 5x7pA-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 1.01A 5x7pB-2a8iA:
undetectable		 5x7pB-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 0.97A 5x7qA-2a8iA:
undetectable		 5x7qA-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 0.95A 5x7qB-2a8iA:
undetectable		 5x7qB-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 0.97A 5x7rA-2a8iA:
undetectable		 5x7rA-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 6 SER A 134
ARG A 172
GLU A 168
TYR A 171
 None
 0.97A 5x7rB-2a8iA:
undetectable		 5x7rB-2a8iA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		5 / 9 ALA A 101
ALA A 266
SER A 251
VAL A 130
GLY A 264
 None
 1.15A 6bklA-2a8iA:
undetectable
6bklB-2a8iA:
undetectable
6bklC-2a8iA:
undetectable
6bklD-2a8iA:
undetectable		 6bklA-2a8iA:
4.81
6bklB-2a8iA:
4.81
6bklC-2a8iA:
4.81
6bklD-2a8iA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 LEU A  76
ASN A 277
LEU A 364
 None
 0.77A 6exiD-2a8iA:
undetectable		 6exiD-2a8iA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 5 ARG A  67
ALA A  68
GLN A  70
ILE A  73
 None
 1.34A 6f6sA-2a8iA:
undetectable
6f6sB-2a8iA:
0.0		 6f6sA-2a8iA:
16.19
6f6sB-2a8iA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		4 / 8 HIS A 296
GLY A 292
GLY A  51
LEU A 232
 None
 0.67A 6mdqA-2a8iA:
0.4		 6mdqA-2a8iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2a8i THREONINE ASPARTASE
1
(Homo
sapiens) 		3 / 3 THR A  83
GLU A  94
ASN A 144
 None
 0.77A 6nj9K-2a8iA:
undetectable		 6nj9K-2a8iA:
23.36