SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 7 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.35A 11gsA-2a8qA:
undetectable		 11gsA-2a8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 7 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.35A 11gsB-2a8qA:
undetectable		 11gsB-2a8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		4 / 8 MET A  61
ALA A  38
LEU A  86
LEU A  94
 None
 0.95A 1ereE-2a8qA:
undetectable		 1ereE-2a8qA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		4 / 8 MET A  61
ALA A  38
LEU A  86
LEU A  94
 None
 0.94A 1ereF-2a8qA:
undetectable		 1ereF-2a8qA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		8 / 9 HIS A  37
ARG A  63
GLY A  72
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
POP  A1307 (-3.3A)
MN  A 300 (-4.6A)
None
None
None
None
None
 1.02A 2a8tA-2a8qA:
34.0		 2a8tA-2a8qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		9 / 9 HIS A  37
ARG A  63
GLY A  73
PHE A  74
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
POP  A1307 (-3.3A)
POP  A1307 (-3.2A)
POP  A1307 (-4.1A)
None
None
None
None
None
 0.38A 2a8tA-2a8qA:
34.0		 2a8tA-2a8qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		8 / 8 HIS A  37
GLY A  69
PHE A  74
THR A 122
ILE A 178
ASN A 180
SER A 181
GLN A 184
 POP  A1307 (-4.1A)
None
POP  A1307 (-4.1A)
None
None
None
None
None
 0.44A 2a8tB-2a8qA:
33.3		 2a8tB-2a8qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 8 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.34A 2gssA-2a8qA:
undetectable		 2gssA-2a8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 8 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.34A 2gssB-2a8qA:
undetectable		 2gssB-2a8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 12 PHE A 172
GLY A 168
ILE A 155
LEU A  68
VAL A 203
 None
 1.06A 2hmyB-2a8qA:
undetectable		 2hmyB-2a8qA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 9 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.30A 3csjB-2a8qA:
undetectable		 3csjB-2a8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 8 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
 None
 1.29A 3n9jA-2a8qA:
undetectable		 3n9jA-2a8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		4 / 9 SER A 207
ALA A 206
LEU A 169
ILE A 200
 YCM  A 174 ( 3.4A)
None
None
None
 0.99A 4xtaA-2a8qA:
undetectable		 4xtaA-2a8qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2a8q U8 SNORNA-BINDING
PROTEIN X29
(Xenopus
laevis) 		5 / 8 ALA A 144
LEU A  98
LEU A  90
LEU A 154
MET A  61
 None
 1.48A 5jqbA-2a8qA:
undetectable
5jqbB-2a8qA:
undetectable		 5jqbA-2a8qA:
21.49
5jqbB-2a8qA:
19.82