SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		5 / 7 LEU A  23
LEU A  17
MET A   1
LEU A  39
GLN A  41
 None
 1.28A 1kt3A-2a8vA:
undetectable		 1kt3A-2a8vA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		4 / 6 LEU A  17
MET A  21
LEU A  23
MET A   1
 None
 0.84A 2kuhA-2a8vA:
undetectable		 2kuhA-2a8vA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		3 / 3 HIS A  42
MET A  21
MET A   1
 None
 1.33A 2vj1A-2a8vA:
undetectable		 2vj1A-2a8vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2a8v RNA BINDING DOMAIN
OF RHO TRANSCRIPTION
TERMINATION FACTOR
(Escherichia
coli) 		3 / 3 ARG A  66
GLU A 108
SER A  70
 C  D   2 ( 2.9A)
C  D   1 ( 3.2A)
None
 0.90A 2xkkA-2a8vA:
undetectable
2xkkC-2a8vA:
undetectable		 2xkkA-2a8vA:
10.84
2xkkC-2a8vA:
10.84