SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  15
GLY A  10
ILE A 140
LEU A   9
GLY A 324
 None
FAD  A 480 (-3.2A)
None
FAD  A 480 (-4.1A)
None
 0.94A 1jg3A-2a8xA:
3.5		 1jg3A-2a8xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  15
GLY A  10
ILE A 140
LEU A   9
GLY A 324
 None
FAD  A 480 (-3.2A)
None
FAD  A 480 (-4.1A)
None
 0.92A 1jg3B-2a8xA:
3.5		 1jg3B-2a8xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 307
GLY A 308
GLY A 312
ILE A 291
GLU A 321
 None
FAD  A 480 (-3.2A)
None
None
None
 0.91A 1nv8B-2a8xA:
2.8		 1nv8B-2a8xA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  15
GLY A  10
ILE A 140
TYR A 305
HIS A 303
 None
FAD  A 480 (-3.2A)
None
None
None
 1.14A 1p91A-2a8xA:
2.2		 1p91A-2a8xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 230
GLY A 178
ALA A 179
GLY A 187
ILE A 229
 None
 0.84A 1rl8B-2a8xA:
undetectable		 1rl8B-2a8xA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 307
GLY A 308
GLY A 312
ILE A 291
GLU A 321
 None
FAD  A 480 (-3.2A)
None
None
None
 0.86A 1sg9B-2a8xA:
2.8		 1sg9B-2a8xA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 307
GLY A 308
GLY A 312
ILE A 291
GLU A 321
 None
FAD  A 480 (-3.2A)
None
None
None
 0.88A 1vq1B-2a8xA:
2.8		 1vq1B-2a8xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 140
ILE A 139
ALA A 138
LEU A   9
ILE A 109
 None
None
None
FAD  A 480 (-4.1A)
None
 1.23A 1xzxX-2a8xA:
undetectable		 1xzxX-2a8xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A   9
GLY A 282
ALA A 138
ILE A 140
 FAD  A 480 (-4.1A)
None
None
None
 0.83A 2aohB-2a8xA:
undetectable		 2aohB-2a8xA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 406
LEU A 397
SER A 447
LEU A 450
LEU A 423
 None
 0.95A 2ceoA-2a8xA:
undetectable		 2ceoA-2a8xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 126
ASP A 127
THR A 114
GLY A 113
 None
None
None
FAD  A 480 (-3.7A)
 0.73A 2f6dA-2a8xA:
undetectable		 2f6dA-2a8xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 277
THR A 114
TYR A 112
ASP A 279
 None
None
FAD  A 480 (-3.4A)
None
 1.05A 2g70B-2a8xA:
2.3		 2g70B-2a8xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 6 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.23A 2vcvB-2a8xA:
1.8		 2vcvB-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.22A 2vcvD-2a8xA:
undetectable		 2vcvD-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.25A 2vcvE-2a8xA:
undetectable		 2vcvE-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 8 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.20A 2vcvF-2a8xA:
undetectable		 2vcvF-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.29A 2vcvH-2a8xA:
undetectable		 2vcvH-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.14A 2vcvI-2a8xA:
undetectable		 2vcvI-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 6 PHE A 350
LEU A 316
PRO A 346
LEU A 420
ALA A 417
 FAD  A 480 ( 4.8A)
FAD  A 480 (-3.7A)
None
None
None
 1.17A 2vcvK-2a8xA:
1.8		 2vcvK-2a8xA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 406
LEU A 397
SER A 447
LEU A 450
LEU A 423
 None
 1.11A 2xn7A-2a8xA:
undetectable
2xn7B-2a8xA:
undetectable		 2xn7A-2a8xA:
21.53
2xn7B-2a8xA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 230
GLY A 178
ALA A 179
GLY A 187
ILE A 229
 None
 0.84A 3cywA-2a8xA:
undetectable		 3cywA-2a8xA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 178
ALA A 179
GLU A 201
PHE A 202
ILE A 267
 None
 1.11A 3id6C-2a8xA:
4.5		 3id6C-2a8xA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 262
VAL A 189
ILE A 174
ARG A  87
 None
 1.01A 3oezA-2a8xA:
undetectable		 3oezA-2a8xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 269
GLU A 201
GLY A 178
ILE A 176
GLY A 180
 None
 1.28A 3ps9A-2a8xA:
8.0		 3ps9A-2a8xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 262
VAL A 189
ILE A 174
ARG A  87
 None
 0.98A 3pyyB-2a8xA:
undetectable		 3pyyB-2a8xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 201
GLY A 178
ALA A 177
PHE A 202
GLU A 219
 None
 1.43A 3s8pB-2a8xA:
0.1		 3s8pB-2a8xA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  12
GLY A  10
GLU A 108
VAL A  94
ALA A  95
 FAD  A 480 (-3.5A)
FAD  A 480 (-3.2A)
None
None
None
 1.21A 3t7vA-2a8xA:
undetectable		 3t7vA-2a8xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 308
GLY A 143
ILE A 140
ASP A 309
PRO A  13
 FAD  A 480 (-3.2A)
FAD  A 480 (-3.2A)
None
FAD  A 480 (-2.8A)
FAD  A 480 (-4.0A)
 1.12A 4dcmA-2a8xA:
2.6		 4dcmA-2a8xA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   7
ALA A 118
LEU A 122
LEU A 121
LEU A 278
 None
 1.16A 4i1rA-2a8xA:
2.7		 4i1rA-2a8xA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 285
LYS A 289
ALA A 141
TYR A 276
GLU A 274
 None
None
FAD  A 480 (-4.6A)
FAD  A 480 (-4.4A)
None
 1.13A 4lg1B-2a8xA:
3.8		 4lg1B-2a8xA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  97
ILE A  31
GLY A  15
ALA A  11
LEU A  42
 MPD  A 590 ( 4.6A)
None
None
None
None
 0.92A 4o1zA-2a8xA:
undetectable		 4o1zA-2a8xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 342
ASP A 341
ARG A 343
PRO A 346
 None
 1.09A 4uhxA-2a8xA:
2.7		 4uhxA-2a8xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 342
ASP A 341
ARG A 343
PRO A 346
 None
 1.09A 4uhxA-2a8xA:
2.7		 4uhxA-2a8xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 141
VAL A   8
GLY A  14
ALA A 320
GLY A 324
 FAD  A 480 (-4.6A)
None
FAD  A 480 (-4.0A)
FAD  A 480 ( 3.9A)
None
 1.28A 4zjzB-2a8xA:
undetectable		 4zjzB-2a8xA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 176
GLU A 201
GLY A 180
GLY A 183
 None
 0.87A 5a06A-2a8xA:
undetectable		 5a06A-2a8xA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 176
GLU A 201
GLY A 180
GLY A 183
 None
 0.85A 5a06C-2a8xA:
undetectable		 5a06C-2a8xA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 201
GLY A 178
ALA A 177
PHE A 202
GLU A 219
 None
 1.49A 5cprB-2a8xA:
undetectable		 5cprB-2a8xA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 197
ILE A 199
GLY A 183
ILE A 182
ILE A 174
 None
None
None
FAD  A 480 (-4.2A)
None
 1.14A 5kqxB-2a8xA:
undetectable		 5kqxB-2a8xA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 125
ILE A 106
THR A 107
MET A 101
 None
 1.19A 5ljcA-2a8xA:
undetectable		 5ljcA-2a8xA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  62
ASP A  65
LEU A  53
 None
 0.75A 5uhbC-2a8xA:
undetectable		 5uhbC-2a8xA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  62
ASP A  65
LEU A  53
 None
 0.65A 5uhcC-2a8xA:
undetectable		 5uhcC-2a8xA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 265
GLY A 268
ILE A 182
ASP A 309
 None
None
FAD  A 480 (-4.2A)
FAD  A 480 (-2.8A)
 0.93A 5vlmH-2a8xA:
0.0		 5vlmH-2a8xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 119
HIS A 303
ASP A 136
ASN A 137
 None
 1.04A 5x7pA-2a8xA:
2.1		 5x7pA-2a8xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 390
GLN A 352
SER A 392
GLY A 393
 None
 0.49A 6ekzA-2a8xA:
undetectable		 6ekzA-2a8xA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 307
GLY A  14
ILE A 331
VAL A   6
ILE A 139
 None
FAD  A 480 (-4.0A)
None
None
None
 1.07A 6emuC-2a8xA:
3.4		 6emuC-2a8xA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  10
GLY A  12
GLU A  33
THR A 142
ASN A 272
 FAD  A 480 (-3.2A)
FAD  A 480 (-3.5A)
FAD  A 480 (-2.6A)
FAD  A 480 (-3.9A)
None
 0.89A 6exiA-2a8xA:
2.5		 6exiA-2a8xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  10
GLY A  12
GLU A  33
THR A 142
ASN A 272
 FAD  A 480 (-3.2A)
FAD  A 480 (-3.5A)
FAD  A 480 (-2.6A)
FAD  A 480 (-3.9A)
None
 0.91A 6exiB-2a8xA:
2.5		 6exiB-2a8xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  12
GLU A  33
THR A 142
ASN A 272
 FAD  A 480 (-3.2A)
FAD  A 480 (-3.5A)
FAD  A 480 (-2.6A)
FAD  A 480 (-3.9A)
None
 0.92A 6exiC-2a8xA:
2.7
6exiD-2a8xA:
2.6		 6exiC-2a8xA:
11.33
6exiD-2a8xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  12
GLU A  33
THR A 142
ASN A 272
 FAD  A 480 (-3.2A)
FAD  A 480 (-3.5A)
FAD  A 480 (-2.6A)
FAD  A 480 (-3.9A)
None
 0.89A 6exiC-2a8xA:
2.7
6exiD-2a8xA:
2.6		 6exiC-2a8xA:
11.33
6exiD-2a8xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 323
ALA A 327
ALA A  11
GLY A  12
ALA A 141
 None
None
None
FAD  A 480 (-3.5A)
FAD  A 480 (-4.6A)
 1.03A 6hwdH-2a8xA:
undetectable
6hwdI-2a8xA:
undetectable		 6hwdH-2a8xA:
11.11
6hwdI-2a8xA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLN A 323
ALA A 327
ALA A  11
GLY A  12
ALA A 141
 None
None
None
FAD  A 480 (-3.5A)
FAD  A 480 (-4.6A)
 1.03A 6hwdV-2a8xA:
undetectable		 6hwdV-2a8xA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2a8x DIHYDROLIPOYL
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 112
ASN A 272
GLU A 274
GLY A 275
 FAD  A 480 (-3.4A)
None
None
None
 0.83A 6n7fA-2a8xA:
44.1		 6n7fA-2a8xA:
15.59