SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		5 / 9 THR A 578
GLY A 679
LEU A 676
SER A 683
GLU A 582
 None
 1.05A 1jhrA-2a98A:
undetectable		 1jhrA-2a98A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		4 / 6 ASP A 484
TYR A 595
PHE A 552
LEU A 581
 None
 1.04A 2w98A-2a98A:
undetectable
2w98B-2a98A:
undetectable		 2w98A-2a98A:
20.22
2w98B-2a98A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		4 / 5 ILE A 608
SER A 609
PRO A 610
PHE A 611
 None
 1.16A 3bjwC-2a98A:
undetectable		 3bjwC-2a98A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		4 / 6 CYH A 485
GLU A 555
PHE A 568
PHE A 584
 None
I3P  A   1 ( 4.4A)
None
None
 1.40A 3m0wB-2a98A:
undetectable
3m0wJ-2a98A:
undetectable		 3m0wB-2a98A:
16.99
3m0wJ-2a98A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		5 / 12 LEU A 599
ARG A 603
GLY A 551
THR A 547
SER A 546
 None
 1.37A 3okxA-2a98A:
undetectable		 3okxA-2a98A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		4 / 6 GLY A 660
TRP A 657
ARG A 501
ARG A 490
 None
 1.04A 4bqfA-2a98A:
undetectable		 4bqfA-2a98A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		4 / 5 LEU A 441
LEU A 444
MET A 636
THR A 642
 None
 1.26A 4do3A-2a98A:
undetectable		 4do3A-2a98A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		5 / 12 LEU A 599
LEU A 622
MET A 487
ARG A 603
LEU A 606
 None
 1.13A 4x1gA-2a98A:
undetectable		 4x1gA-2a98A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens) 		3 / 3 LYS A 559
ILE A 557
ILE A 554
 None
 0.70A 4y0qA-2a98A:
undetectable		 4y0qA-2a98A:
22.44