SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		6 / 12 VAL A 306
LEU A 270
ILE A 256
GLY A 259
ALA A 261
LEU A 223
 None
 1.30A 1eqhA-2a9cA:
undetectable		 1eqhA-2a9cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		6 / 12 VAL A 306
LEU A 270
ILE A 256
GLY A 259
ALA A 261
LEU A 223
 None
 1.29A 1eqhB-2a9cA:
undetectable		 1eqhB-2a9cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_B_DVAB8_0
(GRAMICIDIN A)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 5 VAL A 384
TRP A 457
VAL A 428
TRP A 413
 None
 1.38A 1micA-2a9cA:
undetectable
1micB-2a9cA:
undetectable		 1micA-2a9cA:
4.58
1micB-2a9cA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		3 / 3 PHE A 240
LEU A 219
LEU A 223
 None
 0.68A 1mx1E-2a9cA:
undetectable		 1mx1E-2a9cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 5 GLU A 169
LEU A 153
LEU A 165
LEU A 167
 None
 0.98A 1np1A-2a9cA:
undetectable		 1np1A-2a9cA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 6 LEU A 415
LEU A 386
PRO A 354
VAL A 462
 None
 1.12A 2dqyC-2a9cA:
undetectable		 2dqyC-2a9cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 7 ASP A 321
TYR A 322
ARG A 450
ALA A 297
 None
MTE  A1501 ( 4.8A)
SO4  A7503 (-3.2A)
MTE  A1501 (-3.7A)
 1.22A 2e5dA-2a9cA:
undetectable
2e5dB-2a9cA:
undetectable		 2e5dA-2a9cA:
21.30
2e5dB-2a9cA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 6 ASP A 156
TYR A 258
PHE A 240
LEU A 219
 None
 0.96A 2w98A-2a9cA:
undetectable
2w98B-2a9cA:
undetectable		 2w98A-2a9cA:
20.44
2w98B-2a9cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		5 / 12 PHE A 136
LEU A 345
GLY A 187
LEU A 202
ALA A 297
 MTE  A1501 (-3.5A)
None
None
SO4  A7503 (-3.8A)
MTE  A1501 (-3.7A)
 1.07A 3i5uA-2a9cA:
undetectable		 3i5uA-2a9cA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		5 / 12 TRP A 372
VAL A 379
ARG A 377
ILE A 209
ALA A 125
 None
 1.15A 3ohtA-2a9cA:
undetectable
3ohtB-2a9cA:
undetectable		 3ohtA-2a9cA:
19.26
3ohtB-2a9cA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 6 HIS A 458
GLU A 192
ASP A 205
SER A 191
 None
 1.27A 4apjA-2a9cA:
undetectable
4apjP-2a9cA:
undetectable		 4apjA-2a9cA:
19.40
4apjP-2a9cA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 7 VAL A 290
PHE A 136
GLY A 296
PHE A 135
 None
MTE  A1501 (-3.5A)
MTE  A1501 (-3.8A)
MTE  A1501 (-4.7A)
 0.94A 4ejjB-2a9cA:
undetectable		 4ejjB-2a9cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 5 GLU A 241
ARG A 304
PRO A 251
SER A 315
 None
 1.26A 4k17B-2a9cA:
undetectable		 4k17B-2a9cA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		5 / 12 ASP A 332
THR A 333
TRP A 447
ARG A 197
GLY A 201
 None
None
None
None
SO4  A7503 (-3.2A)
 1.48A 4kn2A-2a9cA:
0.0		 4kn2A-2a9cA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		5 / 12 ASP A 332
THR A 333
TRP A 447
ARG A 197
GLY A 201
 None
None
None
None
SO4  A7503 (-3.2A)
 1.49A 4kn2B-2a9cA:
0.0		 4kn2B-2a9cA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		5 / 12 ASP A 332
THR A 333
TRP A 447
ARG A 197
GLY A 201
 None
None
None
None
SO4  A7503 (-3.2A)
 1.48A 4kn2C-2a9cA:
0.0		 4kn2C-2a9cA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 5 TYR A 258
GLY A 157
ASP A 156
VAL A 287
 None
 1.17A 4nkvD-2a9cA:
undetectable		 4nkvD-2a9cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		3 / 3 ASN A 437
SER A 435
SER A 434
 None
 0.74A 5gsnA-2a9cA:
undetectable		 5gsnA-2a9cA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_2
(ENVELOPE
GLYCOPROTEIN,GP41)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 4 LEU A 449
LYS A 200
LEU A 202
TRP A 204
 None
None
SO4  A7503 (-3.8A)
SO4  A7503 (-4.5A)
 1.40A 5nvpA-2a9cA:
0.0		 5nvpA-2a9cA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 6 GLY A 405
TRP A 408
GLY A 375
GLY A 293
 None
 0.77A 6ag0C-2a9cA:
undetectable		 6ag0C-2a9cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 5 PRO A 356
VAL A 460
GLY A 422
VAL A 360
 None
 1.05A 6ak3B-2a9cA:
undetectable		 6ak3B-2a9cA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2a9c SULFITE OXIDASE
(Gallus
gallus) 		4 / 6 GLN A 318
TRP A 317
HIS A 140
ALA A 297
 None
None
MTE  A1501 (-3.6A)
MTE  A1501 (-3.7A)
 1.47A 6f6jC-2a9cA:
undetectable
6f6jD-2a9cA:
undetectable		 6f6jC-2a9cA:
23.89
6f6jD-2a9cA:
23.89