SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		3 / 3 ASP A 359
LEU A 179
LEU A 181
 None
 0.72A 1ikeA-2a9fA:
undetectable		 1ikeA-2a9fA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 134
ILE A  71
ILE A 169
ALA A 324
ASN A 321
 None
 1.27A 1jtxA-2a9fA:
undetectable		 1jtxA-2a9fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		3 / 3 ASP A 359
LEU A 179
LEU A 181
 None
 0.72A 1np1B-2a9fA:
undetectable		 1np1B-2a9fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 135
ASP A 162
ILE A 169
GLY A 327
ILE A 328
 None
 1.33A 1q8jA-2a9fA:
4.0		 1q8jA-2a9fA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 6 ASP A 113
LEU A 112
VAL A 111
ILE A 110
 None
 0.91A 1s9qA-2a9fA:
undetectable		 1s9qA-2a9fA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		3 / 3 LYS A 206
ASP A 162
ASP A 138
 None
None
MG  A 801 (-2.6A)
 0.79A 2br4A-2a9fA:
4.1		 2br4A-2a9fA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.10A 2h77A-2a9fA:
undetectable		 2h77A-2a9fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.09A 2h79A-2a9fA:
undetectable		 2h79A-2a9fA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.07A 2vdyA-2a9fA:
undetectable		 2vdyA-2a9fA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.07A 2vdyB-2a9fA:
undetectable		 2vdyB-2a9fA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 5 LEU A  10
GLN A  14
LEU A  12
GLU A  13
 None
 0.99A 3h5gA-2a9fA:
undetectable
3h5gB-2a9fA:
undetectable		 3h5gA-2a9fA:
7.54
3h5gB-2a9fA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 7 VAL A 308
MET A 279
ILE A 276
ILE A 295
 None
 0.97A 3hgxA-2a9fA:
undetectable		 3hgxA-2a9fA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 139
GLU A 148
LEU A 136
ASP A 162
SER A 202
 None
 1.25A 3ko0A-2a9fA:
undetectable
3ko0B-2a9fA:
0.1
3ko0C-2a9fA:
undetectable
3ko0D-2a9fA:
undetectable		 3ko0A-2a9fA:
15.98
3ko0B-2a9fA:
15.98
3ko0C-2a9fA:
15.98
3ko0D-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 GLU A 148
LEU A 136
ASP A 162
ILE A 139
SER A 202
 None
 1.25A 3ko0K-2a9fA:
undetectable
3ko0L-2a9fA:
undetectable
3ko0M-2a9fA:
undetectable
3ko0N-2a9fA:
undetectable		 3ko0K-2a9fA:
15.98
3ko0L-2a9fA:
15.98
3ko0M-2a9fA:
15.98
3ko0N-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 202
GLU A 148
LEU A 136
ASP A 162
ILE A 139
 None
 1.18A 3ko0M-2a9fA:
0.2
3ko0N-2a9fA:
undetectable
3ko0O-2a9fA:
undetectable
3ko0P-2a9fA:
undetectable		 3ko0M-2a9fA:
15.98
3ko0N-2a9fA:
15.98
3ko0O-2a9fA:
15.98
3ko0P-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 10 SER A 202
ILE A 139
GLU A 148
LEU A 136
ASP A 162
 None
 1.27A 3m0wC-2a9fA:
undetectable
3m0wD-2a9fA:
undetectable
3m0wE-2a9fA:
undetectable
3m0wF-2a9fA:
undetectable		 3m0wC-2a9fA:
15.68
3m0wD-2a9fA:
15.68
3m0wE-2a9fA:
15.68
3m0wF-2a9fA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 7 GLU A 137
SER A  72
VAL A  70
VAL A 111
 MG  A 801 (-3.0A)
None
None
None
 1.24A 3n61A-2a9fA:
undetectable
3n61B-2a9fA:
undetectable		 3n61A-2a9fA:
21.10
3n61B-2a9fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 11 PHE A 286
GLY A 309
GLY A 264
ALA A 289
ALA A 267
 None
 1.08A 3sufC-2a9fA:
undetectable		 3sufC-2a9fA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.04A 3uboB-2a9fA:
3.1		 3uboB-2a9fA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 5 SER A 277
ILE A 285
GLY A 304
PRO A 283
 None
 1.05A 3uboB-2a9fA:
3.1		 3uboB-2a9fA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.25A 4c49A-2a9fA:
undetectable		 4c49A-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.01A 4c49B-2a9fA:
undetectable		 4c49B-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.05A 4c49C-2a9fA:
undetectable		 4c49C-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
 None
 1.13A 4c49D-2a9fA:
undetectable		 4c49D-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4e3aA-2a9fA:
undetectable		 4e3aA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.01A 4jkuB-2a9fA:
undetectable		 4jkuB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.01A 4k8pA-2a9fA:
undetectable		 4k8pA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4k8pB-2a9fA:
undetectable		 4k8pB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4k8tA-2a9fA:
4.3		 4k8tA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4k8tB-2a9fA:
undetectable		 4k8tB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.01A 4k93A-2a9fA:
3.2		 4k93A-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.03A 4k93B-2a9fA:
undetectable		 4k93B-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.00A 4k9cA-2a9fA:
2.3		 4k9cA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.04A 4k9iA-2a9fA:
undetectable		 4k9iA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.03A 4k9iB-2a9fA:
undetectable		 4k9iB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.00A 4kadA-2a9fA:
3.1		 4kadA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4kadB-2a9fA:
undetectable		 4kadB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4lbxA-2a9fA:
undetectable		 4lbxA-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.02A 4lbxB-2a9fA:
undetectable		 4lbxB-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.00A 4lc4A-2a9fA:
undetectable		 4lc4A-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ASN A 320
ILE A 319
GLY A 311
THR A 364
LEU A 323
 None
 1.03A 4lc4B-2a9fA:
undetectable		 4lc4B-2a9fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.08A 4lnwA-2a9fA:
undetectable		 4lnwA-2a9fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 ILE A 191
ALA A 209
LEU A 172
ILE A 346
PHE A 262
 None
 1.08A 4lnxA-2a9fA:
undetectable		 4lnxA-2a9fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 6 SER A 185
LEU A 186
ASP A 187
LEU A 179
 None
 1.02A 4wozA-2a9fA:
undetectable
4wozB-2a9fA:
undetectable		 4wozA-2a9fA:
22.64
4wozB-2a9fA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		5 / 12 GLY A 196
GLY A 195
ARG A 245
LEU A 201
ALA A 240
 None
 0.92A 5l0zA-2a9fA:
3.3		 5l0zA-2a9fA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))
(Streptococcus
pyogenes) 		4 / 8 ILE A 110
LEU A 112
ILE A  71
ILE A 134
 None
 0.65A 5numA-2a9fA:
undetectable		 5numA-2a9fA:
13.24