SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		3 / 3 SER A 129
GLU A 128
GLU A 127
 None
 0.55A 1eqbD-2a9jA:
undetectable		 1eqbD-2a9jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		3 / 3 SER A 129
GLU A 128
GLU A 127
 None
 0.55A 1eqbB-2a9jA:
undetectable		 1eqbB-2a9jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		6 / 11 ALA A 228
LEU A 222
LEU A 199
HIS A 198
ILE A 173
ALA A 174
 None
 1.28A 1ha2A-2a9jA:
undetectable		 1ha2A-2a9jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		3 / 3 LEU A 158
VAL A 161
LEU A 165
 None
 0.52A 1mz9B-2a9jA:
undetectable		 1mz9B-2a9jA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		4 / 7 GLU A 135
ILE A  96
LEU A  60
TRP A  16
 None
 1.39A 1q0yH-2a9jA:
undetectable
1q0yL-2a9jA:
undetectable		 1q0yH-2a9jA:
22.10
1q0yL-2a9jA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		4 / 8 HIS A 188
SER A 191
ARG A 193
VAL A 161
 None
 1.31A 1u1jA-2a9jA:
undetectable		 1u1jA-2a9jA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		5 / 12 LEU A 199
LEU A 195
ILE A 185
ILE A 173
ALA A 174
 None
 0.99A 2bxqA-2a9jA:
undetectable		 2bxqA-2a9jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		3 / 3 ARG A 117
GLU A 101
SER A 118
 3PG  A 408 (-2.8A)
None
None
 0.94A 2xkkA-2a9jA:
undetectable
2xkkC-2a9jA:
undetectable		 2xkkA-2a9jA:
16.15
2xkkC-2a9jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		6 / 12 ILE A 185
ALA A 187
ARG A 164
LEU A  87
VAL A 177
LEU A 220
 None
 1.38A 3dzyA-2a9jA:
undetectable		 3dzyA-2a9jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		4 / 8 PRO A 213
ILE A 245
ILE A 210
ARG A 117
 None
None
None
3PG  A 408 (-2.8A)
 0.91A 3sfeB-2a9jA:
undetectable
3sfeC-2a9jA:
undetectable		 3sfeB-2a9jA:
20.65
3sfeC-2a9jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		4 / 5 ARG A  21
TYR A 132
PRO A 131
LEU A  98
 None
 1.49A 3tgvC-2a9jA:
undetectable		 3tgvC-2a9jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		4 / 4 LEU A  87
LEU A 165
SER A 192
ALA A 194
 None
 1.12A 5uunA-2a9jA:
undetectable		 5uunA-2a9jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		5 / 12 LEU A 222
LEU A 199
LEU A 195
ILE A 173
ALA A 174
 None
 1.15A 5v0vA-2a9jA:
undetectable		 5v0vA-2a9jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens) 		5 / 12 GLY A 215
THR A 214
GLY A  12
PRO A 213
ASN A  40
 None
 0.98A 5ybbA-2a9jA:
undetectable		 5ybbA-2a9jA:
20.43