SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.64A 1fbmB-2a9sA:
undetectable		 1fbmB-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.67A 1fbmD-2a9sA:
undetectable		 1fbmD-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 5 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.67A 1fbmE-2a9sA:
undetectable		 1fbmE-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		3 / 3 THR A 146
LEU A 150
LEU A 157
 None
 0.66A 1mz9C-2a9sA:
undetectable		 1mz9C-2a9sA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.78A 1mz9D-2a9sA:
undetectable		 1mz9D-2a9sA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 12 VAL A 153
VAL A  56
GLY A  39
ALA A  40
LEU A 150
 None
 0.91A 1r9oA-2a9sA:
undetectable		 1r9oA-2a9sA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 7 ALA A  98
ARG A  97
TYR A  94
PHE A  55
 None
 0.99A 2ajvH-2a9sA:
undetectable
2ajvL-2a9sA:
undetectable		 2ajvH-2a9sA:
21.74
2ajvL-2a9sA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		4 / 8 LEU A 163
LEU A 134
ALA A  89
LEU A  86
 None
 0.78A 2vcvF-2a9sA:
undetectable		 2vcvF-2a9sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 HIS A 135
THR A 105
LYS A  63
GLY A  78
THR A  73
 None
 1.47A 4qvpV-2a9sA:
undetectable
4qvpb-2a9sA:
undetectable		 4qvpV-2a9sA:
23.35
4qvpb-2a9sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 HIS A 135
THR A 105
LYS A  63
GLY A  78
THR A  73
 None
 1.46A 4qvqV-2a9sA:
undetectable
4qvqb-2a9sA:
undetectable		 4qvqV-2a9sA:
23.35
4qvqb-2a9sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 HIS A 135
THR A 105
LYS A  63
GLY A  78
THR A  73
 None
 1.46A 4qvqH-2a9sA:
undetectable
4qvqN-2a9sA:
undetectable		 4qvqH-2a9sA:
23.35
4qvqN-2a9sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 ALA A 156
VAL A  51
ASP A  52
GLY A  35
GLY A  54
 None
 1.02A 4xp4A-2a9sA:
undetectable		 4xp4A-2a9sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 HIS A 135
THR A 105
LYS A  63
GLY A  78
THR A  73
 None
 1.44A 5l66V-2a9sA:
undetectable
5l66b-2a9sA:
undetectable		 5l66V-2a9sA:
23.35
5l66b-2a9sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA
(Agrobacterium
fabrum) 		5 / 11 HIS A 135
THR A 105
LYS A  63
GLY A  78
THR A  73
 None
 1.44A 5l66H-2a9sA:
undetectable
5l66N-2a9sA:
undetectable		 5l66H-2a9sA:
23.35
5l66N-2a9sA:
21.43